Abstract
Parkinson's disease (PD) is a neurodegenerative disorder well known for its progressive loss of dopaminergic neurons in the SNpc, in addition to a part of catecholaminergic neurons of Locus coeruleus (LC), show a significant degeneration in patients. Consequently, evidence shows that the progression of the pathology, as well as the degeneration of the brain nuclei in PD, follows a rostro-…