bachelor's at Biomedical Sciences at Universidade Estadual Paulista Júlio de Mesquita Filho (2002), master's (2005) and doctorate (2009) at Sciences with emphasis in Cancerology from Fundação Antônio Prudente. Actually, Mariana is a research associate at University College Londonl. Has experience in molecular biology, genetics and genomics, focusing on Human and Medical Genetics. (Source: Lattes Curriculum)
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Molecular alterations increase the risk of cancer by increasing DNA damage, changes in the epigenome or the chromatin structure that impact the gene expression, metabolism and ultimately the phenotype exhibited by cancer cells. Identification of regulatory pathways and molecular biomarkers yielded dramatic changes in outcome for several adult cancers, but childhood cancer has largely been…
Pediatric solid tumors comprise 3% of all cancers with approximately 70% of these children becoming adults. The treatment of tumors with poorer prognosis has already reached the limits of tolerance requiring the search for alternative therapies. On the other hand, around one in every 750-1000 adults are survivors of cancer in the childhood and suffer late adverse effects from the aggressi…
DNA molecules contain genetic information about organisms in their composition. Gene expression is the process by which stretches of DNA are transcribed into different types of RNA, coding or non-coding, with the coding being translated into proteins, impacting the phenotype and function of cells. The observation of this process under different conditions is relevant, for example, to iden…
Malignant tumors originating from bone tissue represent between 4% and 8% of childhood cancers, with Osteosarcoma (50%) and Ewing's Sarcoma (40%) being the most frequent. Osteosarcomas present several alterations, however few genes are recurrently mutated, such as TP53, RB1, CDKN2A, MYC, TGFB1. About 90% of Ewing Sarcomas present translocations involving the EWSR1 and FLI1/ERG family of g…
The embryonic Wilms tumors are tumors that exhibit morphological heterogeneity with three components: blastema, epithelia and stroma. Mutations in WT1, CTNNB1, WTX, DROSHA, SIX2, MYCN, TP53, and others less common genes overlap and are found in 30% of the analyzed cases. Moreover, the loss of imprinting of 11p15, resulting in overexpression of IGF2 is found in about 70% of cases. Alone, n…
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 5 / 3 | Completed scholarships in Brazil |
| 10 / 8 | All research grants and scholarships |
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CV Lattes
ORCID