Leoanardo holds a bachelor's degree in Pharmacy-Biochemistry from the Araraquara School of Pharmaceutical Sciences, São Paulo State University "Júllio de Mesquita Filho". (FCFAr-UNESP), where he developed his course completion work on Cosmetic Technology, developing microstructured polymeric systems for topical delivery of anti-oxidants. Leonardo obtained his Master degree in Pharmaceutical Sciences (FCFAr - UNESP), where he evaluated the biological potential of functionalized nanostructured lipid carriers for docetaxel delivery in the treatment of glioblastoma multiforme. Currently, Leonardo is a phD researcher at FCFAr - UNESP, under the guidance of Prof. Dr. Marlus Chorilli, where he develops functionalized nanostructured lipid carriers for intranasal administration of temozolomide in the treatment of glioblastoma multiforme. Areas of concentration: oncology; pharmaceutical technology; lipid nanoparticles; target delivery. (Source: Lattes Curriculum)
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Glioblastoma Multiforme (GBM) is the most incident and most aggressive neoplasm of the Central Nervous System (CNS). Temozolamide (TMZ), the drug of choice for the treatment of GBM, has clinical efficacy, but treatment with this drug is associated with the development of resistance in more advanced stages of the disease, in addition to the fact that TMZ has physical and chemical limitatio…
Glioblastoma (GBM) is the most common primary malignant cancer of the central nervous system, responsible for about 4% of the deaths associated with tumors, characterizing itself as one of the most fatal cancers. Chemotherapy is widely used in treatment and docetaxel (DTX), Taxotere®, is a chemotherapeutic drug that has demonstrated efficacy in GBM treatment, inhibiting cell proliferation…
Vitamins are widely found in the plant kingdom, such as in plants and fruits. Ascorbic acid (AA) is one of these compounds and has a powerful antioxidant activity, in addition to functioning as a skin whitener, fighting free radicals and hyper-pigmentation of the skin. Another important representative compound is nicotinamide (Vitamin B3 or niacinamide), often used in cosmetics to be a pr…
Glioblastoma multiforme (GBM) is the most frequent and most aggressive Central Nervous System (CNS) cancer. Temozolomide (TMZ), the first-line drug for the treatment of GBM, has clinical efficacy, but treatment with this drug is associated with the development of resistance in more advanced stages of the disease, in addition to the fact that TMZ has physical-chemical limitations that hind…
Glioblastoma multiforme (GBM) is the most common primary malignant central nervous system cancer, responsible for about 4% of deaths associated with neoplasia, characterized as one of the most fatal human cancers. Chemotherapy is widely present in the treatment of glioblastoma and, among the commercial available drugs, docetaxel (DTX), Taxotere®, is a chemotherapy that has demonstrated ef…
Vitamins are widely found substances in nature, such as plants, fruits and other products. Ascorbic acid (AA) is one of these compounds and has a powerful antioxidant activity. In addition, it acts as a skin whitener, fighting free radicals and hyper-pigmentation of the skin. Another important representative compound is niacin (Vitamin B3 or niacotinamide), often used in cosmetics as a pr…
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