Abstract
Colistin is a mixture of two polymyxins (PMXs) PMX PMX E1 and E2. It is an antimicrobial drug used to treat infections caused by gram-negative bacteria; and can be obtained from the fermentation of the natural producer, Paenibacillus polymyxa var colistinus. The use of colistin has been avoided in the past because of its nephrotoxic effect, but since multiresistant bacterial infections st…