Abstract
In this proposal, we intend to develop delivery drug systems (DDS) targeted to receptors of IL-12 / IL-23 pro-inflammatory cytokines by specific monoclonal antibodies, seeking to investigate specific uptake and the effect of the drug prednisone in 2D and 3D cellular matrices of the intestinal epithelium of Crohn's disease patients. The DDS aims to improve the therapeutic efficacy of medic…