Abstract
The O-GlcNAc process is characterized by adding a simple carbohydrate [N-acetylglucosamine (GlcNAc)] to the complex hydroxyl (O) from serine (Ser) and threonine (Thr) located in nuclear and cytoplasmic proteins. The increased O-GlcNAc reduces the release of inflammatory mediators such as interleukin-1² (IL-1²), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-±) as well as the a…