Abstract
Prostate-specific antigen (PSA) and digital rectal examination (DRE) are the two main tools in the detection of prostate cancer (PC). However, these methods are not so reliable when used in men with persistent suspicious of PC after an initial negative biopsy. It is known that between 25-30% of men will be diagnosed with PC in the second prostate biopsy. The downside is that the other 70-…