I am a bioinformatics Ph.D. from UNICAMP. I studied multi-omics data analysis, integrative systems biology, and computational biology and modeling. I also have experience with basic experimental (?wet-lab?) protocols involving cell culture, DNA/RNA/Protein extraction, processing and analysis. (Source: Lattes Curriculum)
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The role of the immune response in response to conventional cancer therapy and disease progression or recurrence has been well established for many cancers. The era of checkpoint inhibitors (anti-PD1, anti-CTLA-4, anti-PD-L1, and others) has ushered in novel therapies that aim to activate a previously inhibited anti-cancer T cell response by blocking inhibitory receptor engagement. While …
Stress granules are aggregates of proteins and RNAs found in the cytoplasm of cells, generally produced in response to a form of environmental stress. However, several neurodegenerative diseases, such as amyotrophic lateral sclerosis and Alzheimer's, have already been associated with pathogenic inclusions of these aggregates, which have deleterious consequences to the cell. Among the prot…
RNA-binding proteins regulate post-transcriptionally a large number of genes. It binds to various cellular mRNAs regulating splicing, location, stabilization and degradation of transcripts and act as guides in gene regulation by short non-coding RNAs, such as microRNAs. Mutations or alterations in RBPs or alterations in target mRNA regulations are associated with diseases, failures in mai…
TDP-43 is one the proteins involved in mRNA splicing, during the processing of pre-mRNAs into mature mRNAs transcripts. When TDP-43 is mutated, this process can be compromised and the newly generated transcripts can show sequence errors. Among the flaws related to the process of splicing, there are mutations called "non-sense", which result in the introduction of a premature stop-codon in…
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