Edenir Inêz Palmero

• Abstract

  Breast cancer (BC) is considered a public health problem, being 5% to 10% hereditary. The identification of individuals at risk for hereditary cancer is important because: 1) affected individuals have a much higher cumulative cancer risk, 2) relatives of an affected individual may be at-risk for hereditary cancer, and 3) the existence of intensive screening and preventive intervention me…

  Molecular characterization of at high risk families for hereditary breast cancer, negatives for BRCA1/BRCA2: looking for the BRCAx, AP.R

• Abstract

  Gastric cancer is a very aggressive pathology that still with a frightening prognosis. Despite the decrease of the incidence, the gastric cancer remains as one of the most deadly diseases, being the fourth most diagnosed cancer and the second most deadly cancer in the world. Somatic mutation in the TP53 gene are frequently in gastric tumors. However, the frequency of germline mutations of…

  Evaluation of the presence and frequency of the TP53-p.R337H mutation in gastric cancer of patients at Barretos Cancer Hospital, BP.IC

• Abstract

  Breast cancer is the more frequent tumor type in women, about 5-10% of the cases are hereditary. The main genes associated with a higher breast cancer predisposition are BRCA1, BRCA2, TP53, PTEN, CDH1, STK11 and, more recently, PALB2, a tumor suppressor gene involved in several cellular functions, mainly in the DNA Double-Strand Break (DSB) repair. The genetic variants found in these gene…

  Functional analysis of variants of uncertain significance in the breast cancer predisposition gene PALB2, BP.MS

• Abstract

  It is known that breast and ovarian tumors with germline mutations in BRCA1 or BRCA2 genes are up to 1000 times more sensitive to treatment with PARP inhibitors than wild type tumors. Although, little is known about the effect of these PARP inhibitors on tumors harboring mutations in other genes involved in the homologous recombination mechanism of DNA repair. The objective of this work i…

  Use of PARP inhibitors in breast and ovary cancer cell lines harboring mutations in genes of the homologous recombination DNA repair pathway, BP.MS

(Only some records are available in English at this moment)

• Abstract

  Programmed Death 1 (PD-1) and T cell Ig and mucin domain-3 protein (Tim-3) are immune checkpoint receptors that are expressed on tumor-infiltrating lymphocytes (TIL) in tumor-bearing mice and humans. As anti-PD-1 single agent response rates are only <20% in head and neck squamous cell carcinoma (HNSCC) patients, it is important to understand how multiple inhibitory checkpoint receptors ma…

  Mechanisms of PD-1 and Tim-3 crosstalk in tumor infiltrating lymphocytes, BE.EP.PD