Abstract
Rheumatoid arthritis (RA) is considered an autoimmune disease, characterized by chronic inflammation in the hyperplastic synovial membrane and bone tissue, causing severe joint loss, which is predominantly generated by the increase in the number of osteoclasts. Leukotrienes (LTs) are lipid mediators derived from arachidonic acid via the 5-lipoxygenase (5-Lo) pathway and play an important …