Rodrigo Villares Portugal in research grants and scholarships supported by FAPESP.
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Biological molecules in solution are the basis of life. Vitrified solutions of biological complexes can now be imaged directly in a cryogenic electron microscope (cryo-EM), and provide a window into the functioning of our bio-molecular machinery. However, the molecules only tolerate a very low electron exposure dose and the raw data are thus necessarily very noisy. Huge data sets (~Terab…
The Transmission Electron Microscope (TEM) has, since its invention in the 1930s, played a pivotal role in visualizing the processes of life. Many specimen preparation techniques have been developed for imaging biological samples including Cryogenic Electron Microscopy ("cryo-EM") which is typically aimed at elucidating the structure of vitreous-ice embedded macromolecular complexes. The …
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