Abstract
The purpose of the present study will be to evaluate the bone remodeling of osseointegrated implants installed in tibias of rats modified or not systemically by tamoxifen associated or not to Cisplatin (CIS) or 5-Fluorouracil (5-FU. 252 rats will be used, the animals will receive ovariectomy bilaterally (OVX), tibial implant placement bilaterally and after 6 weeks will be randomized into …