Abstract
Cystic fibrosis (CF) is caused by Cystic FibrosisTransmembrane regulator (CFTR)mutations . The CF clinical variability is associated with CFTR mutations, environmental factors and modifier gene, mainly related to pulmonary disease. Itshould be noted, in this case, the IL-8 gene (interleukin 8), which thepolymorphismhave been related to the CF severity, considering its importanceinimmune r…