CV Lattes
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ORCID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Farmácia Bioquímica from Universidade Estadual de Maringá (2003), master's at Pharmacy from Universidade Estadual de Maringá (2006) and doctorate at Byophysics from Universidade Federal do Rio de Janeiro (2010). Has experience in Microbiology, focusing on Mycology, acting on the following subjects: atividade antifúngica, alfavaca, leveduras, candida sp and alteração ultraestrutural. (Source: Lattes Curriculum)
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Cryptococcosis is an opportunistic disease that causes meningitis. Cryptococcus spp. are considered ideal and facultative intracellular parasites, surviving in macrophages, and using them as a "Trojan horse" to penetrate the blood-brain barrier. This yeast-macrophage interaction is extremely important in the development of the disease and studies have shown that C. neoformans has develope…
Cryptococcus species are etiological agents of cryptococcosis, the cerebral form is the most frequent and severe in HIV/AIDS patients, resulting in high rates of mortality and morbidity. Although antifungal therapy for cryptococcosis is available, it is still ineffective due to the limited antifungal option, side effects, unfavorable pharmacokinetics, and the increase of isolates resistan…
Invasive fungal infections (IFIs) are considered a public health problem that result in high rates of mortality and morbidity. Among the IFIs, Candida albicans represents 50-70% of the cases, followed by Cryptococcus and Aspergillus. However, resistant and emerging species have frequently been isolated, such as Candida auris considered a superbug responsible for outbreaks in hospital on a…
Invasive fungal infections (IFIs) lead a serious health risk resulting in high rates of mortality and morbidity. Among IFIs, Candida albicans represent 50-70% of the cases, followed by Cryptococcus, Aspergillus and Pneumocystis. However, resistant and emerging fungal species have often been isolated, such as Candida auris considered a superfungus. In addition to resistance to antifungal a…
Fungi and bacteria often coexist in polymicrobial biofilms and represent a clinically relevant health problem. Among fungal species Candida albicans is the most frequent in the hospital setting and it is estimated that 27% of C. albicans bloodstream infections (BIs) are polymicrobial, wherein Stapholococcus aureus and Pseudomonas aeruginosa sre the common bacterial species isolated togeth…
The research for new antifungal agents remains a challenge for the scientific community, and synthetic substances and natural products, are the most frequently studied for the development of antifungal. Miltefosine, an alkylphospholipids analog used in the treatment of visceral leishmaniasis, has shown good antifungal activity against different species of yeast and filamentous fungi. Howe…
(Only some records are available in English at this moment)
Cryptococcus is the etiological agent of cryptococcosis, and it is estimated that there are 180,000 deaths and more than 270,000 annual cases of the disease worldwide, a fact associated with the immunosuppression of patients, the virulence factors of the fungus and the limited arsenal of antifungals to treat cryptococcosis. It is known that autophagy, apoptosis, and necrosis can occur phy…
Cryptococcosis is an opportunistic disease that causes meningitis. Cryptococcus spp. are considered ideal and facultative intracellular parasites, surviving in macrophages, and using them as a "Trojan horse" to penetrate the blood-brain barrier. This yeast-macrophage interaction is extremely important in the development of the disease and studies have shown that C. neoformans has develope…
Candida auris was described in 2009, and joined the World Health Organization's critical priority group of fungi in 2022. It is an opportunistic pathogen that colonizes abiotic surfaces and the skin, being related to high mortality rates and difficulty of containment among patients in intensive care units. Some countries had their first case of C. auris infections during the COVID-19 pand…
(Only some records are available in English at this moment)
Dental cavities is one of the most common diseases afflict to human beings. This illness depends on multiple factors to infect the oral environment of an individual, one of the main etiological factors being dental plaque. The dental plaque, a polymicrobial biofilm, shows cariogenic factors that originate from interactions between distinct microorganisms present in its composition. Amidst…
Cryptococcosis is a mycosis caused by Cryptococcus spp. with high incidence in HIV/AIDS patients leading to high rates of mortality and morbidity. Current therapy is based on the combination of antifungals amphotericin B, fluconazole and 5-fluorocytosine. Although resistance to antifungals in Cryptococcus is relatively uncommon, the risk of developing tolerance or heteroresistance in pati…
Aspergillus fumigatus infections are frequent in immunocompromised individuals and rely on biofilm formation that is associated with increased tolerance to antimicrobials and reinfections. A three-dimensional polymeric model forming a scaffold covered by lung cells can mimic the alveolar microenvironment in which this pathogen is found and thus become an important model for studying host-…
(Only some records are available in English at this moment)
Cryptococcosis is a mycosis caused by Cryptococcus spp. with high incidence in HIV/AIDS patients leading to high mortality and morbidity rates. The current therapy of the severe clinical form, cryptococcal meningitis, is based on the combination of amphotericin B with fluconazole and flucytosine. However, factors such as high toxicity, unfavorable pharmacokinetics, high cost and unavailab…
| 3 / 3 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 10 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 24 / 23 | All research grants and scholarships |
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