Abstract
The neuromyelitis optica (NMO) is inflammatory diseases, autoimmune disorder with predilection for optic nerve and spinal cord mediated by antibodies to aquaporin 4 (AQP4), a protein of the water channels with high expression in the CNS. The anti- aquaporin 4 (NMO-IgG) was discovered in 2004 and in addition to being diagnostic for the spectrum of NMO is related to pathogenesis of disease.…