Abstract
Hematopoiesis is the process of blood cell production which occurs in the bone marrow (BM) microenvironment, which is composed by two anatomically and functionally distinct niches: the endosteal and vascular. The endosteal niche hosts hemopoietic stem cells (HSC) in quiescence /self-renewal and the vascular niche are the HSC in proliferation /differentiation. CTH can be divided into two g…