CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
DVM - Universidade de Brasília (2006). Master - Allergology and Clinical Immunology - UFMUSP (2009). PhD in Immunology - Universidade de São Paulo (2011). Post doctoral at the Division of Endocrinology, Metabolism and Diabetes, Beth Israel Deaconess Medical Center, Harvard Medical School. Professor in Immunology at the university of Campinas. The areas of research include: immunometabolism, diabetes and obesity. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Los efectos del covid-19 |
| News published in Agência FAPESP Newsletter about the researcher |
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The growing interest in Immunometabolism is fueled by the global obesity epidemic and obesity-induced inflammation is a risk factor for several chronic pathologies and diseases. The field of Immunometabolism is the new frontier for Immunology as it integrates the historically distinct disciplines of Metabolism and Immunology. Studies on macrophage metabolic adaptation largely relies in t…
The biochemical of activities occurring in mitochondria are linked to mitochondria morphology. For example, the spatial segregation of biochemical pathways ultimately controls oxidative phosphorylation and energy generation. Systemic and tissue-derived cues shape mitochondria through fission/fusion events, which orchestrates how mitochondria will function. In the immune system, effector c…
The world population is getting older and older. Unfortunately, this increased life expectancy is generally associated by so-called age-related vascular diseases, such as dementia, heart infarct, and stroke, which profoundly compromise the quality of life of the elderly. Age-related disorders are generally viewed as necessary evil. Our project challenges this dogma, as we propose that the…
The pandemic of the new severe acute respiratory syndrome virus (SARS-CoV-2) has already been confirmed in more than 700,000 people on all continents and has been responsible for more than 20,000 deaths worldwide (World Health Organization - official data of March 27, 2020). The only way to treat severe cases is through respiratory support with still unsatisfactory results. To date, there…
The field of Immunometabolism is the new frontier for Immunology as it integrates the historically distinct disciplines of Metabolism and Immunology. The growing interest in Immunometabolism is fueled by the global obesity epidemic and the strong association between inflammation and metabolic disease. Obesity-induced inflammation is a risk factor for several chronic pathologies and diseas…
Immune cells play a central role in maintaining the whole-body homeostasis. Immune cells are constantly adapting their metabolism and function upon systemic alterations. Immunometabolism has helped to understand how these cells are important in physiological and pathological conditions. Macrophages have different activation profiles and metabolic adaptations in different contexts and micr…
Macrophages are essential cells for tissue homeostasis and constitute the first line of host defense. Macrophages activated with LPS and IFN-³ acquire a pro-inflammatory profile characterized by NF-kB activation, which in turn induces cytokine expression, such as IL-6, IL-1², and TNF-±, and the production of nitric oxide by inducible nitric oxide synthase (iNOS). To acquire this profile, …
LXRs (liver x receptors) are nuclear receptors that act as sensors of cholesterol levels in the body. LXRs play a crucial role in the regulation of lipids metabolism, transport and efflux. LXRs are found in two isoforms, LXRalpha and beta. LXRalpha is primarily found in intestine, liver, and adipose tissue, while LXRbeta is expressed in almost all cell types. Once bound to a ligant, LXRs…
(Only some records are available in English at this moment)
The ongoing COVID-19 (Coronavirus Disease 2019) pandemic caused by the new Severe Acute Respiratory Syndrome virus (SARS-CoV-2), has already been confirmed in more than 8 million people on all continents and has been responsible for more than 450 thousand deaths worldwide (World Health Organization - WHO, official data of June 19, 2020). This virus mainly affects the respiratory system, w…
The study of immune cell metabolism has resulted in a major advance in understanding the immune system regulation under both physiological and pathological conditions. There is a constant metabolic adaptation so leukocytes can survive, proliferate and perform their functions. Depending on the energy and biosynthetic needs, different leukocytes and their subtypes acquire different metaboli…
Obesity is a disease that affects millions of people worldwide. It is marked by a systemic low grade pro-inflammatory profile. Obesity-induced hyperleptinemia is a result of hypothalamic resistance to leptin. Leptin is produced by adipose tissue in response to food intake and acts on the hypothalamus, exerting control over ingestion. This adipokine also has pro-inflammatory properties. Ce…
(Only some records are available in English at this moment)
Multiple sclerosis (MS) is considered a T-cell mediated autoimmune disease. Thus the study of the mechanisms that control the T cell response, as well as innovative strategies to modulate the pathways that control T-cell polarization by antigen-presenting cells (APCs) is likely to result in new therapeutic approaches. In this application we propose to study the mechanisms by which the tra…
Obesity epidemic affects more people each year and is an important risk factor for type 2 diabetes. During obesity, there is an increase in white adipose tissue, which is accompanied by leukocyte infiltration, especially of pro-inflammatory. This classically activated macrophage phenotype (M1) produce pro-inflammatory cytokines (TNF-± and IL-1²), which leads to adipose tissue inflammation…
It is still not entirely elucidated how pathological conditions with excess of nutrients (glucose and lipids) and growth factors (leptin, insulin) in obesity and insulin resistance can modulate metabolic function of immune cells. Leptin is an adipokine produced by the adipose tissue and regulates food intake. Leptin concentration indicates the amount of energy available to be used by the …
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 15 / 15 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 32 / 32 | All research grants and scholarships |
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