Abstract
KGA (kidney-type glutaminase) is an isoform of mitochondrial glutaminase (GA) - enzyme responsible for catalyzing the conversion of glutamine to glutamate - encoded by the GLS1 gene. This reaction is the first step in the glutaminolysis pathway, a key process for tricarboxylic acid cycle (TCA) anapleurosis in order to provide biosynthetic precursors for the maintenance of the proliferativ…