CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Centro Universitário São Camilo (2006), graduation at Análise e Desenvolvimento de Sistemas from Faculdade de Tecnologia - Ipiranga (2013), master's at Biochemistry from Universidade Federal de São Paulo (2009) and doctorate at Biochemistry from Universidade Federal de São Paulo (2014). Has experience in biochemistry and biophysics, focusing on Molecular Biology, acting on the following subjects: g-protein coupled receptors, angiotensin ii, toac, receptor b2 and receptores. Furthermore has experience in Genetics field focusing on Next Generation Sequencing, analysis of whole exome sequencing and system coding for sequencing analysis automation. (Source: Lattes Curriculum)
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The studies of human genetics have been applied to better understand how differences of DNA sequence act on the natural physiology of each person triggering several genetic associated disorders to produce new treatment or prevention protocols. Based on the sequence of target genes involved on diagnosed disease it is possible to elucidate several control path of each mutation exert on its …
Previous study reported that in CHO cell line transfected with the AT1 receptor an unespexted tachyphylaxis phenomenon to [Lys2]-AII was showed. This effect was ascribed to the lack of the 3 and 5 untranslated regions (3, 5-UTR) in the cDNA for AT1 receptor. Furthermore whereas the tachyphylaxis was specific to AII in rabbit arterial smooth muscle cell line that expresses endogenous AT1 r…
A series of site-directed mutagenesis of recombinantly expressed AT1 receptor combined with the modification of AII have led to the identification of several contacts between AII and its receptor, important for biochemical and pharmacological characterization. Previous studies have provided evidence that S-S bridge established between Cys101 and Cys180 is crucial for the binding and activ…
The hereditary angioedema (HAE) is an autosomal dominant inherited disease characterized by painful edema episodes with variable localization and severity. Most of diagnosed patients present either mutation on C1 inhibtor gene (C1-INH), with abnormal levels or functionality (HAE type I and II, respectively) or Factor 12 (FXII) gene (HAE Type 3). These mutations leads to a super production…
| 3 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
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