Graduated in Pharmacy Biochemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1982), Master of Pharmacy (Clinical Analysis) from the University of São Paulo (1985) and Ph.D. in Biochemistry Sciences from the University of São Paulo (1989). Currently she is professor of the Universidade Estadual Paulista Júlio de Mesquita Filho. She has experience in Pharmacy, with emphasis on Immunology, acting on the following subjects: immune response in sporotrichosis, emerging fungal infection by increasing the number of cases zoonotic with the cat as the main animal carrying the disease. Through its Master's, Doctoral and Post-Doctoral studies, the role of Toll Like Receptors (TLRs) as triggers of the immune response against the S. schenckii fungus has been evaluated, as well as the role of the NLRP3 inflammasome and the receptor of dectin-1 in this infection. Regarding the treatment has evaluated the antifungal activity by the use of amphotericin B cochleate and the activity of natural products against the fungus. As for the studies of prevention and / or prophylaxis the research has advanced a lot with regard to obtaining a vaccine product in sporotrichosis. (Source: Lattes Curriculum)
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The ability to form immunological memory is considered a hallmark of adaptive immunity. However, increasing evidence suggests that innate immune cells, including natural killer cells, can also "remember" prior exposures to certain stimuli, responding at a higher magnitude upon a secondary immune stimulation. First described in 1975, based on their capability to eliminate allogeneic tumor …
Sporotrichosis is an important fungal disease with worldwide distribution that affects humans and animals. Among the species in the complex, S. schenckii sensu stricto is the causal agent present in all countries, while S. brasiliensis is especially found in Brazil, where this infection is already considered an important zoonosis. Many cases of sporotrichosis caused by cat scratches and c…
Sporotrichosis is a mycotic disease of subacute and chronic evolution with cutaneous or subcutaneous nodular lesions, and less frequently disseminated in people with immunological compromise. The causal agent is a dimorphic fungus of the genus Sporothrix which is part of a complex of different species, among them, S. brasiliensis, S. globosa, S. mexicana and S. schenckii sensu stricto of …
Sporotrichosis is an important mycosis with worldwide distribution that affects humans and animals. The infection is usually caused by traumatic inoculation of the fungus Sporothrix schenckii complex (composed of: S. brasiliensis, S. globosa, S mexicana and S. schenckii luriei strict sense) and clinical manifestations can range from skin infection, lymphocutaneous and systemic infection, …
(Only some records are available in English at this moment)
Sporotrichosis is endemic in Latin America and hyperendemic in Brazil, where for more than two decades has been presented as zoonosis transmitted by cats infected with the fungus Sporothrix brasiliensis. Regulatory CD4+ T cells characterized by the expression of molecules CD25, FOXP3 and CTLA-4 are responsible for efficacy of self-tolerance mechanisms and regulation of immune response es…
Sporotrichosis is a subcutaneous fungal infection of subacute or chronic evolution, caused by pathogenic species of the genus Sporothrix. It has a cosmopolitan geographic distribution and is considered an endemic zoonosis in Brazil, transmitted by cats infected by S. brasiliensis, the most pathogenic species among the Sporothrix genus. Cases of sporotrichosis were only reported in the Sta…
Sporotrichosis is a fungal disease that affects humans, and other mammals, caused by the pathogenic species of the genus Sporothrix. The disease has a worldwide distribution, endemically affecting Latin America, especially Argentina, Chile, and Brazil, and it is very widespread in the cosmopolitan area. The numbers of clinical cases have been broadly reported in Brazil, where the disease …
(Only some records are available in English at this moment)
The present project proposes to use the Foxp3 gene silencing technology to evaluate the influence of T regulatory cells (Tregs) on the immune response against a vaccine of wall proteins and a recombinant enolase-based vaccine against S. schenckii. The effect of Tregs depletion on the primary and secondary response will be evaluated separately and simultaneously. The use of the DEREG trans…
It has been suggested that fungal-bacterial mixed-species biofilms may be more virulent as a result of cross-kingdom interaction mediated by fungal cell-wall's mannans. We aim to evaluate the role of beta-mannanase on mixed-species biofilm development through the disruption of mannan-mediated bacterial-fungal interaction. Specifically, this study aims to determine the effects of beta-mann…
Sporotrichosis is a chronic infection affecting humans and other mammals, caused by species of the genus Sporothrix. The disease has a worldwide distribution, but it is considered an endemic zoonosis in Brazil, mainly in the state of Rio de Janeiro and the metropolitan areas of São Paulo city. The antifungal treatment is very prolonged and often associated with adverse effects, being the …
| 1 / 1 | Ongoing research grants |
| 14 / 11 | Completed research grants |
| 28 / 21 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 46 / 36 | All research grants and scholarships |
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CV Lattes
ORCID