CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Pharmacy Biochemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1982), Master of Pharmacy (Clinical Analysis) from the University of São Paulo (1985) and Ph.D. in Biochemistry Sciences from the University of São Paulo (1989). Currently she is professor of the Universidade Estadual Paulista Júlio de Mesquita Filho. She has experience in Pharmacy, with emphasis on Immunology, acting on the following subjects: immune response in sporotrichosis, emerging fungal infection by increasing the number of cases zoonotic with the cat as the main animal carrying the disease. Through its Master's, Doctoral and Post-Doctoral studies, the role of Toll Like Receptors (TLRs) as triggers of the immune response against the S. schenckii fungus has been evaluated, as well as the role of the NLRP3 inflammasome and the receptor of dectin-1 in this infection. Regarding the treatment has evaluated the antifungal activity by the use of amphotericin B cochleate and the activity of natural products against the fungus. As for the studies of prevention and / or prophylaxis the research has advanced a lot with regard to obtaining a vaccine product in sporotrichosis. (Source: Lattes Curriculum)
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Sporotrichosis is a mycotic disease of subacute and chronic evolution with cutaneous or subcutaneous nodular lesions, and less frequently disseminated in people with immunological compromise. The causal agent is a dimorphic fungus of the genus Sporothrix which is part of a complex of different species, among them, S. brasiliensis, S. globosa, S. mexicana and S. schenckii sensu stricto of …
Sporotrichosis is an important mycosis with worldwide distribution that affects humans and animals. The infection is usually caused by traumatic inoculation of the fungus Sporothrix schenckii complex (composed of: S. brasiliensis, S. globosa, S mexicana and S. schenckii luriei strict sense) and clinical manifestations can range from skin infection, lymphocutaneous and systemic infection, …
Sporotrichosis is commonly caused by traumatic inoculation of thermo-dimorphic fungus Sporothrix schenckii in the skin or subcutaneous tissues, as a zoonosis from animal scratches or injuries involving soil. Previous studies on a sporotrichosis animal model showed an increased host susceptibility period during infection's acute phase with depressed immune response. This susceptibility has…
(Only some records are available in English at this moment)
Sporotrichosis is a fungal disease caused by species of the Sporothrix schenckii complex, which can affect animals and humans. The most frequently clinical manifestation is the lymphocutaneos form which begins with a nodular or ulcerated lesion at the site of traumatic inoculation of the fungus on the skin. Despite the protective mechanisms of this tissue to aggressive agents, when the sk…
Sporotrichosis is a worldwide distributed subcutaneous mycosis, mainly in tropical and subtropical countries, and it is considered to be emerging in Brazil and other countries. The causative agents are species from the Sporothrix schenckii complex that live in the soil. Among the species of the complex, S. schenckii sensu strictu is the causative agent present in all countries, whereas S.…
Sporotrichosis is a worldwide distributed, although especially present in tropical and subtropical regions, acute or chronic subcutaneous mycosis caused by thermodimorphic fungi from the Sporothrix schenckii species complex. It is commonly caused by the traumatic inoculation of the fungus from contaminated soil, plants, and organic material, affecting both humans and animals. The zoonotic…
(Only some records are available in English at this moment)
The present project proposes to use the Foxp3 gene silencing technology to evaluate the influence of T regulatory cells (Tregs) on the immune response against a vaccine of wall proteins and a recombinant enolase-based vaccine against S. schenckii. The effect of Tregs depletion on the primary and secondary response will be evaluated separately and simultaneously. The use of the DEREG trans…
It has been suggested that fungal-bacterial mixed-species biofilms may be more virulent as a result of cross-kingdom interaction mediated by fungal cell-wall's mannans. We aim to evaluate the role of beta-mannanase on mixed-species biofilm development through the disruption of mannan-mediated bacterial-fungal interaction. Specifically, this study aims to determine the effects of beta-mann…
Sporotrichosis is a chronic infection affecting humans and other mammals, caused by species of the genus Sporothrix. The disease has a worldwide distribution, but it is considered an endemic zoonosis in Brazil, mainly in the state of Rio de Janeiro and the metropolitan areas of São Paulo city. The antifungal treatment is very prolonged and often associated with adverse effects, being the …
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| 25 / 18 | Completed scholarships in Brazil |
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