CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade Estadual de Londrina (1985), master's at Genetics from Universidade Federal do Rio Grande do Sul (1990) and ph.d. at Biologia Molecular from Gesellshaft Fur Biotechnologische Forshung (1994). Has experience in Biochemistry, acting on the following subjects: interação proteína-proteína, processamento de rna, interação proteína-rna, saccharomyces cerevisiae and expressão gênica. (Source: Lattes Curriculum)
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In eukaryotes, RNAs undergo many processing steps before becoming functional; these steps require specific protein-protein and protein-RNA interactions that are essential for the control of gene expression. We have characterized the function of various yeast proteins, involved in different steps of RNA processing. The RNase named exosome has been the main focus of the research in my group…
The research in our group has focused mainly in the study of the exosome complex, present in organisms ranging from archaea to mammals, in which it is involved in processing and degradation of all classes of RNAs. We have been studying the function of the exosome in the yeast Saccharomyces cerevisiae and the structure of the archaeal and yeast complexes. In this project, we intend to cont…
Eukaryotic ribosome biogenesis is an elaborate process during which ribosomal proteins assemble with the pre-rRNA while it is being processed and folded. Hundreds of assembly factors (AF) are required and transiently recruited to assist the sequential remodeling events. One of the most intricate ones is the stepwise removal of the internal transcribed spacer 2 (ITS2), between the 5.8S and…
In eukaryotes, RNAs undergo many processing steps for becoming functional; these steps require specific protein-protein and protein-RNA interactions that are essential for the control of gene expression. We have characterized the function of various yeast proteins, involved in different steps of RNA processing. The research in our group has focused mainly in the study of the exosome compl…
Prof. John McCarthy is Head of the School of Life Sciences in the University of Warwick (UK). His institution offers a number of graduate students exchange programs and training courses in advanced techniques for the study of systems biology, protein interaction within large complexes, and bioinformatics.Prof. McCarthy has shown great interest in establishing collaborations between groups…
(Only some records are available in English at this moment)
The exosome complex is one of the most versatile RNA degradation machineries ineukaryotes. It plays an important role in the biogenesis of various RNAs (rRNAs,snoRNAs, snRNAs, ncRNAs) and in the regulation of specific mRNA expressionlevels both in the nucleus and cytoplasm. The exosome acts at various stages ofRNA processing and degradation and has 3'-5' exoribonucleolytic activit…
Protein phosphorylation regulates the activity, localization, stability, and interaction with other ligands. The process of ribosomal biogenesis is highly complex, being dynamically controlled by the action of specific protein-protein and RNA-protein interactions, which are essential for the control of gene expression. The RNase called exosome has been the central focus of research of our…
All RNAs transcribed in eukaryotic cells undergo maturation stages. One of the steps that pre-mRNAs go through is the splicing process, where the non-coding sequences (introns) are removed and the coding sequences (exons) joined. For this process to occur, two transesterification reactions are necessary, which in turn are mediated by a multimeric complex called a spliceosome, composed of …
(Only some records are available in English at this moment)
The Exosome is a protein complex involved in the processes of RNA degradation and processing in eukaryotes. In the cell nucleus, the exosome acts in the processing of rRNAs, with catalytic activity of 3'-5 'exonuclease. This complex interacts with different cofactors in each region of the cell, whose main function is to recruit it for substrate degradation / processing and also to activat…
Splicing is a maturation process of pre-mRNAs, essential in eukaryotes, through which intron sequences are extracted from the precursor mRNAs, allowing the ligation of the exons and the formation of the protein coding sequences. Over a hundred factors are involved in this process, and among them, the protein Cwc24, which binds the intron 5'-end, protecting it from premature nucleophilic a…
The R2TP co-chaperone complex (Rvb1, Rvb2, Tah1 and Pih1/ Nop17) is evolutionarily conserved and mediates the interaction of the Hsp90 chaperone with target proteins and complexes. R2TP-Hsp90 assists maturation of several protein complexes, such as box C/D snoRNPs, U4 and U5 snRNP and RNA polymerase II. Nop17 plays a central role in the complex because it acts on the structural cohesion o…
(Only some records are available in English at this moment)
In vivo Fe-S cluster assembly into target apo-proteins requires a complex and conserved biosynthetic machinery. In non-green eukaryotes two systems are dedicated to mature Fe-S cluster containing proteins, known as ISC (Iron-Sulfur Cluster Assembly) and CIA (Cytosolic Iron-Sulfur Protein Assembly) systems. The ISC system takes place inside mitochondria and is responsible for the direct ma…
The exosome is a multiprotein complex involved in the processing of almost every RNA in the cell. Exosome main functions include non-coding RNA degradation, mRNA turnover and ribosomal RNA maturation. In Saccharomyces cerevisiae cells, the exosome is present in both the nucleus and the cytoplasm, but the composition of the complex varies depending on the cellular location. The nuclear exo…
Pre-RNA splicing is an essential step on gene regulation in eukaryotes. Splicing is the removal of introns and ligation of exons in mature RNA sequences and is performed by the spliceosome, a ~4 MDa macromolecular machinery composed of 5 snRNAs (small nuclear RNAs) and more than a hundred proteins, many of which are conserved from yeasts to mammals. Spliceosome assembly is a dynamic proce…
| 2 / 2 | Ongoing research grants |
| 15 / 9 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 25 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 2 | Completed scholarships abroad |
| 50 / 29 | All research grants and scholarships |
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