Abstract
Cyclooxygenase 2 (COX-2) and p-Akt1 are associated with tumor spreading, cell proliferation, high metabolism, and angiogenesis in solid tumors. This study aimed to investigate COX-2 and p-Akt1 expression in primary and metastatic melanomas, through correlation with the cellular proliferation index (as revealed by minichromosome maintenance 2 [Mcm-2] expression) and the outcome of patients…