CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas (FCA) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Professor at the State University of Campinas at the School of Applied Sciences of UNICAMP. Graduated in Physical Education by PUC-Campinas (2002) and completed master's degree (2007), doctorate (2010) and postdoctoral (2011) at the Faculty of Medical Sciences of UNICAMP. Concluded post-doctorate at the École Polytechnique Fédérale de Lausanne (EPFL - Switzerland), supervised by Dr. Johan Auwerx. Dr. Ropelle is a researcher at the National Institute of Science and Technology in Obesity and Diabetes and the OCRC - Center for Research on Obesity and Comorbidities (CEPID / FAPESP). Currently, he coordinates a Thematic research project from FAPESP. He has an experience in the molecular biology of the exercise, investigating the effects of exercise in mouse models of obesity, diabetes and aging. (Source: Lattes Curriculum)
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The prevalence of overweight and obesity is increasing over the years and one of the main causes is the inappropriate lifestyle including overnutrition and sedentarism. Excessive consumption of saturated fat alters the functionality of hypothalamic cells that control whole-body energy homeostasis. High-fat diets can affect mitochondrial activity in microglia and neurons in the hypothala…
In the last two decades, neuroinflammation was considered a biological response that was only a supporting factor in the etiopathogenesis of Alzheimer's Disease. However, preclinical studies and more recent studies confirm the involvement of the immune system in the pathogenesis of Alzheimer's Disease. In this context, cytokine-10 (IL-10) came to be considered as a key molecule in the con…
Excessive consumption of saturated fat alters the functionality of hypothalamic neurons that control energy homeostasis, directly contributing to the onset of the obese phenotype. Mitochondrial activity in subpopulations of hypothalamic neurons is closely related to the control of food intake and energy homeostasis. Consumption of high fat diets promotes deleterious signals that alter the…
Mitonuclear imbalance and UPRmt (mitochondrial Unfolded Protein Response) are cellular phenomena activated under stress conditions and involving mitochondrial metabolism. These responses are largely related to mitochondrial biogenesis, improved mitochondrial function and cell metabolism, and increased longevity in several organisms. Mitonuclear imbalance is characterized by the alteratio…
The mitochondrial unfolded protein response (UPRmt), it is recognized as an adaptive intracellular pathway in response to stress, which ensures the integrity and function of the mitochondrial proteome through the mitochondrial chaperone and protease action. Mutagenic studies have shown that the disturbance caused by the stoichiometric imbalance between the mitochondrial DNA proteins (mtDN…
Accumulating evidence has demonstrated that S-nitrosation of proteins plays a critical role in several human diseases. Here, we explored the role of inducible nitric oxide synthase (iNOS)in the S-nitrosation of proteins involved in the early steps of the insulin-signaling pathway and insulin resistance in the skeletal muscle of aged mice. Aging increased iNOS expression and S-nitrosation …
(Only some records are available in English at this moment)
Alzheimer's disease is a progressive and fatal neurodegenerative disorder which manifests especially by cognitive, behavioral and motor deterioration. The disease is considered a global priority of public health, both by the poor prognosis associated with the significant health commitment and the lack of effective treatments in disease management. The disease is especially characterized b…
The hypothalamus plays an important role in the regulation of energy and homeostasis. This structure of the central nervous system is responsible for integrating signals from peripheral hormones, including insulin and leptin, which have a decisive role in controlling food intake and energy expenditure. Subpopulations of neurons located in the arcuate nucleus of the hypothalamus (ARC) are …
Mitochondrial activity in hypothalamic neurons plays a critical role in the control of food intake and energy homeostasis. The consumption of high fat diet can promote deleterious signals, altering proteostasis and mitochondrial activity. In response to different types of cellular stress, mitochondria activate a mechanism known as mitochondrial Unfolded Protein Response (UPRmt) to maintai…
(Only some records are available in English at this moment)
Mitochondria are the main site of intracellular energy production, according to the endosymbiotic theory, it originated from a bacterium that at some point was engulfed by the process of endocytosis by eukaryotic cells. As the relationship symbiotic relationship was of mutual benefit, this association prevailed, the main advantage of to keep the mitochondria incorporated, it was because o…
(Only some records are available in English at this moment)
Obesity is a metabolic syndrome caused by an imbalance between energy expenditure and consumption, where the hypothalamus play a major role in appetite control and energy homeostasis. Caenorhabiditis elegans is a nematode that can be as obesity model due they fatty acid metabolism. Mitochondria is an important multifunctional organelle related to energy metabolism through ATP production t…
Alzheimer's disease (AD) is a progressive neurodegenerative disease that results in cognitive impairment of affected patients. The etiology of the disease is multifactorial, with contributing factors that include genetic markers such as the amyloid precursor protein (APP), presenilin (PS) 1 and apoelipoprotein E (ApoE), and others such as smoking, dyslipidemia, the inflammatory process. I…
Obesity is classified as a low-grade chronic inflammation, accompanied by resistance to insulin and leptin, hormones directly associated with energy homeostasis. Mitochondrial activity in hypothalamic arcuate nucleus neurons is closely related to the control of food intake and energy homeostasis. Mitochondria is a dynamic organelle and changes its conformation according to cellular energe…
The aging process is characterized by a progressive loss of physiologic integrity, leading to impaired function, reducing the physical and mental capacity, increasing the risk of disease and finally increasing vulnerability to death. Changes in the body composition may influence the lifespan, once there is an increasing in the fat mass and a decrease in muscle mass during the aging proce…
In mammals, the food intake and energy expenditure are strongly regulated for specifically neurons localized in the hypothalamus. The hypothalamus controls the energy food and energy expenditure through of hormonal and nutritional signals. A main nutrient related the food intake control is the glucose. Studies link that the lost selective of glucose sensibility in the hypothalamic neurons…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 23 / 20 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 41 / 38 | All research grants and scholarships |
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