CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas (FCA) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Professor at the State University of Campinas at the School of Applied Sciences of UNICAMP. Graduated in Physical Education by PUC-Campinas (2002) and completed master's degree (2007), doctorate (2010) and postdoctoral (2011) at the Faculty of Medical Sciences of UNICAMP. Concluded post-doctorate at the École Polytechnique Fédérale de Lausanne (EPFL - Switzerland), supervised by Dr. Johan Auwerx. Dr. Ropelle is a researcher at the National Institute of Science and Technology in Obesity and Diabetes and the OCRC - Center for Research on Obesity and Comorbidities (CEPID / FAPESP). He has an experience in the molecular biology of the exercise, investigating the effects of exercise in mouse models of obesity, diabetes and aging. (Source: Lattes Curriculum)
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Excessive consumption of saturated fat alters the functionality of hypothalamic neurons that control energy homeostasis, directly contributing to the onset of the obese phenotype. Mitochondrial activity in subpopulations of hypothalamic neurons is closely related to the control of food intake and energy homeostasis. Consumption of high fat diets promotes deleterious signals that alter the…
Mitonuclear imbalance and UPRmt (mitochondrial Unfolded Protein Response) are cellular phenomena activated under stress conditions and involving mitochondrial metabolism. These responses are largely related to mitochondrial biogenesis, improved mitochondrial function and cell metabolism, and increased longevity in several organisms. Mitonuclear imbalance is characterized by the alteratio…
The mitochondrial unfolded protein response (UPRmt), it is recognized as an adaptive intracellular pathway in response to stress, which ensures the integrity and function of the mitochondrial proteome through the mitochondrial chaperone and protease action. Mutagenic studies have shown that the disturbance caused by the stoichiometric imbalance between the mitochondrial DNA proteins (mtDN…
Accumulating evidence has demonstrated that S-nitrosation of proteins plays a critical role in several human diseases. Here, we explored the role of inducible nitric oxide synthase (iNOS)in the S-nitrosation of proteins involved in the early steps of the insulin-signaling pathway and insulin resistance in the skeletal muscle of aged mice. Aging increased iNOS expression and S-nitrosation …
(Only some records are available in English at this moment)
Mitochondrial metabolism in specific subpopulations of hypothalamic neurons plays a critical role in the control of food intake and energy homeostasis. Excessive consumption of diets high in saturated fats can trigger deleterious signals to hypothalamic neurons, including neuroinflammation, oxidative stress, and reduced mitochondrial activity. Under cellular stress conditions, mitochondri…
Mitochondria are the main site of intracellular energy production, according to the endosymbiotic theory, it originated from a bacterium that at some point was engulfed by the process of endocytosis by eukaryotic cells. As the relationship symbiotic relationship was of mutual benefit, this association prevailed, the main advantage of to keep the mitochondria incorporated, it was because o…
Mitochondria present in hypothalamic neurons are essential for the control of energy homeostasis. The consumption of diets rich in saturated fats can promote changes in the functioning of these organelles in some subpopulations of hypothalamic neurons, promoting changes in the signals that control satiety and body energy expenditure, contributing to the development of the obese phenotype.…
(Only some records are available in English at this moment)
Hepatic fat accumulation is an event often seen in obese patients and can cause metabolic disorders such as inflammation, mitochondrial disfunction, insulin resistance, leading to hepatic steatosis and cirrhosis. Pre-clinic studies shows that oral treatment with NAD+ precursors can stimulate mtUPR (mitochondrial unfolded protein response) mechanism, recovering mitochondrial and hepatic fu…
Lipolysis is a complex biological mechanism responsible for promoting the degradation of fat molecules to obtain an energy substrate. The aging process is accompanied by increased accumulation of adipose tissue by which occurs at least in part, due to the reduction lipolysis activation capacity. On the other hand, it is known that physical exercise is recognized as a potent stimulator of …
Recent studies indicate that the maintenance of mitochondrial activity in hypothalamic neurons is a determinant for the control of energy homeostasis in mammals. It is known that the abundance of NAD + levels induces potent mitochondrial signals, promoting increased oxidative capacity and increased mitochondrial biogenesis. Among these signs, we highlight the induction of "mitonuclear imb…
(Only some records are available in English at this moment)
The aging process is characterized by a progressive loss of physiologic integrity, leading to impaired function, reducing the physical and mental capacity, increasing the risk of disease and finally increasing vulnerability to death. Changes in the body composition may influence the lifespan, once there is an increasing in the fat mass and a decrease in muscle mass during the aging proce…
In mammals, the food intake and energy expenditure are strongly regulated for specifically neurons localized in the hypothalamus. The hypothalamus controls the energy food and energy expenditure through of hormonal and nutritional signals. A main nutrient related the food intake control is the glucose. Studies link that the lost selective of glucose sensibility in the hypothalamic neurons…
The hypothalamus is a structure of central nervous system responsible for control several body functions, such as, energy expenditure, body temperature, and food intake. Recent studies indicates an intriguing relationship between the hypothalamus and skeletal muscle metabolism, once that different hypothalamic nucleus are responsible, at least in part by glucose uptake, atrophy, insulin s…
| 1 / 1 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 16 / 13 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 32 / 29 | All research grants and scholarships |
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