CV Lattes
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Sociedade Brasileira de Biologia Celular (SBBC) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor in Dentistry from the Universidade Estadual Paulista - UNESP, Master in Science (Human Physiology) from the Universidade de São Paulo and PhD in Science (Cell and Tissue Biology) from the Universidade de São Paulo. Post-Doc from the University of Tennessee, USA (1994-1997) and from the National Institute of Craniofacial Research - NICDR-NIH, USA (2007-2008). Since 2010 has been a Full Professor at the Institute of Biomedical Sciences at the University of São Paulo. Coordinator of the Graduation Course in Cell and Tissue Biology at USP (currently Life Systems Biology) between 2010 and 2015 and currently participates in the Program's Coordinating Committee. Co-founder (2008) and President of the Research Support Facility Center - CEFAP/USP (2017 to 2020) and Coordinator of the Multiphotonic Confocal Microscopy Laboratory at CEFAP/USP between 2008 and 2020. Treasurer of the Brazilian Society of Biology Celular (SBBC) since 2010 and has actively participated in the organization of scientific events by SBBC. Currently Head of Department of Cell and Developmental Biology at the Institute of biomedical Sciences at USP. Associate Editor of the Brazilian Dental Science Journal. Has experience in Morphology, focusing on Cytology and Cell Biology, acting on the following topics: cell migration, cytoskeleton, cell signaling, extracellular matrix, hyperglycemia, microRNAs and wound healing. (Source: Lattes Curriculum)
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Using in vitro and in vivo systems, we have studied the role of chronic hyperglycemia present in Diabetes Mellitus (DM) on migration and function of fibroblasts. Impaired wound healing is a common complication of DM and contributes to the formation of chronic wounds, which reduce patient's life quality and entail enormous costs for the public health system. We demonstrated deleterious eff…
Deficient wound healing in diabetic patients is one of the most common complications of hyperglycemia (HG) and is associated with microangiopathy, neuropathy and fibroblasts dysfunction. Some studies using fibroblasts from diabetic patients or fibroblasts cultured under conditions that simulate HG showed changes in cell proliferation and ECM protein synthesis. Few studies, however, have a…
Cell migration is an essential process during development, for tissue homeostasis, for the defense system, during wound healing and also for the development and progression of several diseases, such as cancer. Tumor invasiveness is directly related to the ability of tumor cells to migrate and invade surrounding normal tissues, spreading via blood and lymphatic circulation. In wound healin…
(Only some records are available in English at this moment)
Diabetes mellitus (DM) is characterized by chronic hyperglycemia (HG), in a long-term is associated mainly with complications of oxidative stress and glycation. One of the common complications of diabetes is chronic wound; addition to impairment of the vascular system, there are studies suggesting the involvement of specific functions of fibroblasts, important cells in the healing process…
Diabetes Mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, which damages different cells and tissues. A common long term complication of DM is wound healing impairment, a problem that significantly reduces life quality for the patients. The main mechanisms involved in DM complications are oxidative stress and extracellular matrix (ECM) protein glycation. Glycati…
During epithelial tumor invasion, proteins that regulate cell-cell interactions, the loss of apical-basal polarization and increased cell motility are differentially expressed. This process is known as epithelial-mesenchymal transition (EMT), and is partially regulated by small molecular weight GTPases from the Rho family (from Ras-Homology). Although much is known about the role of Rho …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 11 / 6 | Completed research grants |
| 18 / 5 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 31 / 12 | All research grants and scholarships |
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