Denise M. Palomari Spolidorio a degree in Biological Sciences from Catholic University of Campinas (1986) and obtained a Master's degree (1992) and PhD (1996) in Pathology Oral-Dental Biology from State University of Campinas - UNICAMP and Postdoctoral in University of Calgary, Canada (2007). Is Associate Professor, Department of Physiology and Pathology of Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP, 1C Researcher of CNPq. She has worked in dentistry, with emphasis in microbiology, with emphasis on the following topics:. Streptococcus mutans, Candida spp, cariogenic microorganisms, periodontal disease and herbal agents in the control of oral infections. (Source: Lattes Curriculum)
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The development of membranes for bone or tissue regeneration, with good mechanical properties, predictable rate of degradation, low cost, and structure similar to the extracellular matrix is of great interest to the area of nanobiotechnology and tissue engineering. Within this context, scaffolds of nanofibers present morphological characteristics capable of promoting greater cell/matrix-c…
The persistent bacterial biofilm on the implant surface and in the root canal system is the most common etiological factor for peri-implantitis and endodontic infections, with the presence of aerobic and anaerobic microorganisms, and the available antimicrobial treatments seek to reduce the microbial load, eliminate inflammation of the peri-implant mucosa, as well as decontamination of th…
Fungal and bacterial infections mouth has been increasingly reported in the literature. Alternative therapies for microbial control are being developed particularly for resistant microorganisms. Plant extracts and phytochemicals compounds open new perspectives for prevention and efficient control of infectious diseases in the search for favorable therapeutic effects. Terpinen-4-ol is a mo…
Periodontitis is a infection caused by certain microorganisms, such as Porphyromonas gingivalis which is one of the most important pathogens. The major virulence factors of this bacteria is the endodoxin lipopolysaccharide (LPS) that induces an inflammatory response in the individual and lead a exacerbated production of cytokines, which consequently leads to destruction of tooth supportin…
(Only some records are available in English at this moment)
Alternative therapies combining natural products and nanobiotechnologies open new perspectives for controlled drug release. In this context, nanostructured lipid systems (NLS) show promising results due to their structural design and outstanding biological properties. Hesperitin (HT) is a metabolite of hesperidin, found mainly in citrus fruits, with several biological properties such as a…
Scaling and Root Planing (SRP) is the treatment of choice for non-surgical management of Periodontal Disease (PD). Nevertheless, this usual intervention might show limitations or insufficient outcomes when used as a unique therapy in certain clinical cases. Thus, alternative therapies have been investigated to overcome SRP deficiencies that may be related to the limited access to the root…
The development of membranes for bone or tissue regeneration, with good mechanical properties, predictable rate of degradation, low cost, and structure similar to the extracellular matrix is of great interest to the area of nanobiotechnology and tissue engineering. Within this context, scaffolds of nanofibers present morphological characteristics capable of promoting greater cell/matrix-c…
Dental caries is still considered one of the most prevalent oral diseases, despite the prevention methods used. Streptococcus mutans is associated with the etiology of dental caries, which is a chronic infectious disease associated with the progressive destruction of dental structures by the acidogenic/aciduric action of bacteria. Microbial adhesion is an important early event for success…
The use of bioactive and low cost drugs appears as a promising alternative. Hesperitin is a metabolite of hesperidin in the flavonone subgroup with effective therapeutic properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, analgesic and beneficial effects on bone metabolism. Considering the biological properties of hesperitin and aiming to identify compounds tha…
Candida spp. is a fungal pathogen that has the capacity to form oral biofilms. Systemic and extrinsic factors such as poor oral hygiene, the use of ill-fitting dentures, and little salivation are predisposing to the development of candidiasis. The development of new treatment options has been studied since there is a need to limit the resistance created by the fungi to existing antifungal…
(Only some records are available in English at this moment)
Nanofibers is a new class of biomaterials with a wide range of possible applications to the area of nanobiotechnology and tissue engineering. Due to their different characteristics, nanofibers can promote greater cell/matrix-cell interaction, as well as the incorporation of bioactive molecules, reinforcing their biological properties. Hesperitin is a hesperidin metabolite with effective t…
| 1 / 1 | Ongoing research grants |
| 15 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 19 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 39 / 18 | All research grants and scholarships |
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CV Lattes
ORCID