Abstract
Regulatory T cells (Treg) include two major subsets: natural Treg, which recognize auto-antigens, and induced Treg, CD4+CD25- T lymphocytes which, under specific stimulatory conditions, differentiate into CD4+CD25+Foxp3+ cells with suppressor activity and which can recognize foreign antigens or antigens from infectious agents. Using an isogenic murine model for PCM developed in our labora…