José Maurício Sforcin is a biologist and obtained his PhD in 1996 at the São Paulo State University (UNESP). Currently, he is a Full Professor at the Institute of Biosciences, where he is head of the Lab "Immunomodulation by Natural Products". His research interests are in the role of natural products (predominantly propolis and its constituents) in Applied Immunoloy and Microbioloy.He hold several editorial positions, including Guest Editor (Frontiers in Pharmacology, Biology and Evidence-based Complementary and Alternative Medicine).Among the top 100,000 scientists according to research conducted in 2020, 2021 and 2022 byt the University of Stanford (EUA). Included in the AD Scientific Index - World Scientist and University Rankings 2023. (Source: Lattes Curriculum)
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Propolis has attracted the interest of researchers due to its potential for new drug development. This bee product has a complex chemical composition, which varies according to the vegetal sources used by bees. In this study, we aim at investigating a more recently analyzed propolis sample produced from Mimosa tenuiflora (Willd.) Poir., commonly known as "jurema-preta", in the northeast c…
The Brazilian propolis produced by Apis mellifera called green, brown and red have great economic importance, due to their biological activities and export to several countries, such as Japan and China, and production of approximately 200 tons per year. The main botanical origins of Brazilian propolis are: Baccharis dracunculifolia for green propolis; Araucaria sp, Eucalyptus sp and other…
Propolis is a resinous product made by bees from different parts of plants, showing several pharmacological properties with possible application in the pharmaceutical and food industry. Most of the papers on propolis and immunity were performed with animals, and there are few studies with humans regarding its immunomodulatory action. Recently, we initiated the studies with human cells eva…
Dendritic cells (DCs) are essential for recognizing pathogens and presenting their antigens to T lymphocytes, playing a key role in the link between the innate and adaptive immune responses. In this context, modulation of immune response is extremely important for the resolution of the infection. Propolis is a resinous product, made by bees from various plant parts, and has attracted the …
(Only some records are available in English at this moment)
Propolis is a resinous substance produced by bees exhibiting several biological activities, such as antimicrobial and immunomodulatory. Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have been a problem faced by health institutions and the pharmaceutical industry, due to the resistance to most existing ²-lactam antibiotics. Thus, it is mandatory to study the actio…
Literature data demonstrate that preeclampsia (PE) is an important pregnancy syndrome, resulting from sterile inflammation. Endogenous triggering factors are known as damage-associated molecular patterns (DAMPs), such as Hsp70 and HMGB1. The release of DAMPs associated with oxidative stress, induced by monocyte activation, high production of pro-inflammatory cytokines, free radicals, adhe…
HIV infection represents one of the major public health problems due to its pandemic feature and severity. The therapy combining different antiretroviral drugs (cART) has resulted in increased survival of vírus-infected patients but also led to side effects such as cytotoxicity, metabolic disorders, persistent immune activation and inflammation. The goal of this work is to investigate whe…
One of the current challenges in the study of HIV/aids is a better understanding of the chronic inflammation that infected-people present, because the immune activation persists even using antiretroviral therapy (cART), and patients suffer not only with immunodeficiency, but mainly with immunesenescence. These mechanisms contribute to the development of non-aids comorbidities, such as car…
Cancer is a disease that affects millions of people in different continents, resulting in millions of deaths annually. In order to study new therapeutic approaches for cancer treatment, tumor cell lines such as MCF-7 have been used in in vitro assays. Tamoxifen has been used to treat breast cancer. Considering the side effects caused by anticancer agents, such as toxicity, induction of re…
(Only some records are available in English at this moment)
Propolis, a resinous product made by honeybees from exudates collected from different parts of the plants, has shown plenty of therapeutic properties, such as immunomodulatory, antimicrobial, anti-inflammatory, antioxidant, among others. The chemical complexity of propolis is a consequence of the local flora used as a vegetal source for its production, making it difficult to identify the …
| 1 / 1 | Ongoing research grants |
| 17 / 9 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 25 / 15 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 46 / 28 | All research grants and scholarships |
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