CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Assis. Faculdade de Ciências e Letras (FCL-ASSIS) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (2005), master's at Psychology from Universidade de São Paulo (2009) and doctorate at Psychology from Universidade de São Paulo (2013). Has experience in Physiology, focusing on Neorofisiology, acting on the following subjects: serotonina, núcleo mediano da rafe, imobilização, medo condicionado and hipocampo dorsal. (Source: Lattes Curriculum)
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The ability to detect and predict threatening or stressful events is essential for our survival. Although recent studies have focused on mPFC as a fundamental structure in modulation of the emotionality, and the hypothalamus has also been implicated in the regulation of these processes, and the hypothalamic neuropeptide orexin (hypocretin) appears to be involved in the processing of state…
The ability to detect and predict threatening or stressful events is essential for survival. The medial prefrontal cortex (mPFC) has been the target of several studies in neuroscience since the participation of this structure in mnemonic processes and in the control of emotions is investigated. The hypothalamus has also been implicated in the regulation of such processes, and the hypothal…
The ability to detect and predict threatening or stressful events is essential for survival. The medial prefrontal cortex (mPFC) has been the target of several studies in neuroscience since the participation of this structure in mnemonic processes and in the control of emotions is investigated. The hypothalamus has also been implicated in the regulation of such processes, and the hypothal…
The study of the neuropsychopharmacological bases of the fear- and panic-related behaviour has been the focus of several scientific researches. The mesencephalic tectum (MT) has been considered as responsible for the control of defensive responses evoked during threatening situations. The deep layers of the superior colliculus (dlSC) and the dorsal columns of the periaqueductal grey matte…
Anxiety disorders belong to the most common psychiatric disorders with enormous burden to the patient and the society. Many of them are precipitated by stress and associated with exaggerated fear responses, which often result from classical and operant conditioning processes. In this context, studies in animal models revealed the importance of the two stress hormone systems with adrenali…
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 4 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 8 / 7 | All research grants and scholarships |
| Associated processes | |
CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; DOS ANJOS-GARCIA, TAYLLON; FALCONI-SOBRINHO, LUIZ LUCIANO; PASCHOALIN-MAURIN, TATIANA; BAZAGLIA-DE-SOUSA, GUILHERME; MEDEIROS, PRISCILA; DA SILVA, JULIANA ALMEIDA; LOBAO-SOARES, BRUNO; COIMBRA, NORBERTO CYSNE. Panicolytic-like effect of mu(1)-opioid receptor blockade in the inferior colliculus of prey threatened by Crotalus durissus terrificus pit vipers. JOURNAL OF PSYCHOPHARMACOLOGY, v. 33, n. 5, p. 577-588, MAY 2019. (07/01174-1, 15/10313-1, 17/11855-8, 09/02458-9, 12/03798-0, 12/22681-7, 17/13560-5, 13/10984-8, 12/25167-2)
DA SILVA, JULIANA ALMEIDA; BIAGIONI, AUDREY FRANCISCO; ALMADA, RAFAEL CARVALHO; DE SOUZA CRIPPA, JOSE ALEXANDRE; CECILIO HALLAK, JAIME EDUARDO; ZUARDI, ANTONIO WALDO; COIMBRA, NORBERTO CYSNE. Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon. European Journal of Pharmacology, v. 758, p. 153-163, JUL 5 2015. (07/01174-1, 09/02458-9, 12/03798-0, 12/22681-7, 10/15140-4, 09/54014-7, 14/10742-7)
ALMADA, R. C.; COIMBRA, N. C.; BRANDAO, M. L.. MEDIAL PREFRONTAL CORTEX SEROTONERGIC AND GABAERGIC MECHANISMS MODULATE THE EXPRESSION OF CONTEXTUAL FEAR: INTRATELENCEPHALIC PATHWAYS AND DIFFERENTIAL INVOLVEMENT OF CORTICAL SUBREGIONS. Neuroscience, v. 284, p. 988-997, JAN 22 2015. (11/00041-3, 12/22681-7)
DA SILVA, JULIANA ALMEIDA; BIAGIONI, AUDREY FRANCESCHI; ALMADA, RAFAEL CARVALHO; DE FREITAS, RENATO LEONARDO; COIMBRA, NORBERTO CYSNE. Panicolytic-like effects caused by substantia nigra pars reticulata pretreatment with low doses of endomorphin-1 and high doses of CTOP or the NOP receptors antagonist JTC-801 in male Rattus norvegicus. Psychopharmacology, v. 234, n. 20, p. 3009-3025, OCT 2017. (14/11869-0, 07/01174-1, 15/10313-1, 17/11855-8, 09/02458-9, 12/03798-0, 12/22681-7, 09/17258-5, 13/12916-0, 10/15140-4, 09/54014-7, 14/10742-7)
CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; DA SILVA, JULIANA ALMEIDA; MEDEIROS, PRISCILA; SOARES, JR., RAIMUNDO DA SILVA; DE PAIVA, YARA BEZERRA; RONCON, CAMILA MARRONI; COIMBRA, NORBERTO CYSNE. The Blockade of mu(1)- and kappa-Opioid Receptors in the Inferior Colliculus Decreases the Expression of Panic Attack-Like Behaviours Induced by Chemical Stimulation of the Dorsal Midbrain. NEUROPSYCHOBIOLOGY, v. 78, n. 4, p. 218-228, NOV 2019. (09/54014-7, 12/23238-0, 15/10313-1, 09/02458-9, 07/01174-1, 12/25167-2, 12/03798-0, 17/13560-5, 12/22681-7)
ALMADA, R. C.; RONCON, C. M.; ELIAS-FILHO, D. H.; COIMBRA, N. C.. ENDOCANNABINOID SIGNALING MECHANISMS IN THE SUBSTANTIA NIGRA PARS RETICULATA MODULATE GABAergic NIGROTECTAL PATHWAYS IN MICE THREATENED BY URUTU-CRUZEIRO VENOMOUS PIT VIPER. Neuroscience, v. 303, p. 503-514, SEP 10 2015. (12/03798-0, 12/22681-7, 12/23238-0)
DE OLIVEIRA, RITHIELE CRISTINA; DE OLIVEIRA, RICARDO; FALCONI-SOBRINHO, LUIZ LUCIANO; BIAGIONI, AUDREY FRANCESCHI; ALMADA, RAFAEL CARVALHO; DOS ANJOS-GARCIA, TAYLLON; BAZAGLIA-DE-SOUSA, GUILHERME; KHAN, ASMAT ULLAH; COIMBRA, NORBERTO CYSNE. Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception. Physiology & Behavior, v. 194, p. 162-169, OCT 1 2018. (09/00668-6, 11/09850-1, 12/22681-7, 08/08955-1, 14/10742-7, 13/10984-8)
ALMADA, RAFAEL C.; GENEWSKY, ANDREAS J.; HEINZ, DANIEL E.; KAPLICK, PAUL M.; COIMBRA, NORBERTO C.; WOTJAK, CARSTEN T.. Stimulation of the Nigrotectal Pathway at the Level of the Superior Colliculus Reduces Threat Recognition and Causes a Shift From Avoidance to Approach Behavior. FRONTIERS IN NEURAL CIRCUITS, v. 12, MAY 7 2018. (15/09116-7)
COIMBRA, NORBERTO CYSNE; CALVO, FABRICIO; ALMADA, RAFAEL CARVALHO; FREITAS, RENATO LEONARDO; PASCHOALIN-MAURIN, TATIANA; DOS ANJOS-GARCIA, TAYLLON; ELIAS-FILHO, DAOUD HIBRAHIM; UBIALI, WALTER ADRIANO; LOBAO-SOARES, BRUNO; TRACEY, IRENE. OPIOID NEUROTRANSMISSION MODULATES DEFENSIVE BEHAVIOR AND FEAR-INDUCED ANTINOCICEPTION IN DANGEROUS ENVIRONMENTS. Neuroscience, v. 354, p. 178-195, JUN 23 2017. (07/01174-1, 12/22681-7, 12/03798-0)
BASSI, G. S.; CARVALHO, M. C.; ALMADA, R. C.; BRANDAO, M. L.. Inhibition of substance P-induced defensive behavior via neurokinin-1 receptor antagonism in the central and medial but not basolateral nuclei of the amygdala in male Wistar rats. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 77, p. 146-154, JUL 3 2017. (12/22681-7)
DA SILVA, JULIANA ALMEIDA; ALMADA, RAFAEL CARVALHO; DE FIGUEIREDO, REBECA MACHADO; COIMBRA, NORBERTO CYSNE. Blockade of synaptic activity in the neostriatum and activation of striatal efferent pathways produce opposite effects on panic attack-like defensive behaviours evoked by GABAergic disinhibition in the deep layers of the superior colliculus. Physiology & Behavior, v. 196, p. 104-111, NOV 1 2018. (07/01174-1, 15/10313-1, 09/02458-9, 12/03798-0, 12/22681-7, 09/54014-7)
DA SILVA, JULIANA ALMEIDA; ALMADA, RAFAEL CARVALHO; DE PAIVA, YARA BEZERRA; COIMBRA, NORBERTO CYSNE. Endocannabinoid neuromodulation in the neostriatum decreases the GABAergic striato-nigral disinhibitory function and increases the nigro-collicular inhibitory pathway activity. JOURNAL OF NEURAL TRANSMISSION, v. 127, n. 8, JUN 2020. (19/01713-7, 17/11855-8, 15/10313-1, 09/02458-9, 07/01174-1, 12/03798-0, 18/03898-1, 12/22681-7)