Abstract
Elevated Plasma Free Hemoglobin (PFHb) occurs in hemolytic anemia and is associated with a reduced half live of circulating erythrocytes. Sickle cell disease (SCD), hereditary spherocytosis (HS), and paroxysmal nocturnal hemoglobinuria (PNH) all share some complications caused by excess PFHb. SCD is characterized by a single mutation in the beta globin gene resulting in an anomalous hemog…