Bachelor in Biomedicine from the Federal University of São Paulo (UNIFESP), Master of Science from the Postgraduate Program in Biology/Genetics from the Institute of Biosciences of the University of São Paulo (USP), and PhD from the Postgraduate Program in Oncology of the Faculdade of Medicine at the University of São Paulo (FMUSP) at the Molecular Biology Laboratory of the Center for Translational Investigation in Oncology of the Cancer Institute of the State of São Paulo (CTO-ICESP). Currently, I'm a postdoctoral fellow in the same department. During my Ph.D., I carried out a research internship abroad at the International Agency for Research on Cancer of the World Health Organization. (Source: Lattes Curriculum)
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The E6 and E7 genes encode the HPV oncoproteins that play a central role in the viral life cycle and malignant transformation. The expression of these oncoproteins depends especially on the activation of the viral promoter contained in the Long Control Region (LCR). In addition, this region contains regulatory elements where cellular Transcription Factors (TFs) bind. The repertoire of TFs…
Human papillomavirus (HPV) type most worldwide prevalent in pre-invasive tumors and in invasive carcinomas of the cervix is the HPV-16 , followed by HPV-18. However, HPV-18 predominates in adenocarcinomas (56%) and adenosquamous tumors (39% ). Several evidences indicate that synchronization of the virus life cycle by epithelial differentiation program, in addition to epitheliotropism, is …
In recent years, the importance of microenvironment in the tumor progression has been more fully understood and new ways to manipulate it have been searched in order to prevent or reduce the development of cancer. The mesenchymal stem cells (MSCs) have emerged as an interesting strategy to reach cancer cells due to the ability of these multipotent cells have to migrate to sites of inflamm…
Cutaneous human papillomavirus (HPV) types from the beta genus are ubiquitously distributed throughout the human body and may be part of the commensal flora. The association of beta-HPVs and the development of cutaneous squamous cell carcinomas (cSCC) were initially reported in patients with the rare genetic disorder Epidermodysplasia verruciformis (EV). About half of EV patients harbor m…
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CV Lattes
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