CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Guilherme Burgarelli Leite in research grants and scholarships supported by FAPESP.
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Tet proteins are 2-oxoglutarate (2OG) and Fe(II) dependent dioxygenases that catalyse the hydroxylation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) in DNA, acting as an intemediate product either during active or passive demethylation, contributing with the DNA methylation dinamics (Koh et al., 2011; Tahiliani et al., 2009). The DNA methylation patterns are altered durin…
During the malignant transformation of melanocytes, like other cellular types, DNA methylation patterns are found altered, affecting the genetic expression. A significative quantity of methylated cytosines (5mC) appears to be hydroxylated (5hmC) by 2-oxoglutarate and Fe(II) dependent dioxygenases, Tet1, 2, and 3 (Globish et al., 2010; Ko et al., 2010). There is evidence pointing 5hmC as a…
Our in vitro melanoma progression model employs substrate adhesion blockade as a malignant transforming factor. The cell lines corresponding to steps of melanoma progression are: melan-a (non-tumorigenic melanocytes), 4C (pre-malignant melanocytes), 4C11- (non-metastatic melanoma cells) and 4C11+ (metastatic melanoma cells). The gene and protein levels of TET2 and 5hmC levels are found to…
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 3 / 3 | All Scholarships |
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