Abstract
Linezolid, the first agent of the oxazolidinone class to be introduced clinically, is potentially active against important bacterial pathogens, including methicillin-resistant Staphylococcus spp. and vancomycin-resistant Enterococcus spp.. This new oxazolidinone inhibits protein biosynthesis by binding to the peptidyl transferase center (PTC) of the 50S subunit of the bacterial ribosome. …