Ana Paula Ramos in research grants and scholarships supported by FAPESP.
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Biominerals are commonly found in nature in the form of hybrid organic-inorganic compounds, in which the organic portion is mainly composed by proteins and polyssacharides. On it is turn, the in the inorganic portion carbonates and phosphates can be found, mainly as hydroxyapatite (HAp) and silica. The process by which these exquisite minerals are formed is named biomineralization and can…
The synthesis of highly-ordered nanostructured materials that offer specific responses when submitted to an external stimulus is one of the application of nanotechnology. The ability to investigate substances at the molecular level started the search for materials with improved properties to medical applications. The use of these molecularly-controlled materials gave rise to a new researc…
Biomineralization is the processes from which minerals are formed in living organisms. This process generates complexes systems like bones, tooth, and pearls (nacre), in which organic matrices formed by macromolecules as lipids and proteins are bonded chemicaly and/or physically being responsible for the modifications in the local supersaturation of the ions which origins the nucleation a…
The demographic displacement of population aging and the appearance of chronic diseases can affect the regenerative capacities of tissues, including bone and cartilage tissue. These problems trigger the search for biomaterials able to support the regenerations and healing of these tissues. In this perspective, the use of strontium and flavonoids for bone and cartilagerelated therapies hav…
One of the main research fields related to tissue engineer aims to obtain biomimetics materials able to stimulate cartilage regeneration using materials similar in structure and composition to this tissue, composed basically by cells called chondrocytes and extracellular matrix. These biomimetic materials must stimulate cell viability and function maintenance also with controlled rage of …
Design of three-dimensional hybrid and injectable templates (scaffolds) has emerged as a promisor approach to produce biomaterials for targeted applications. In this sense, the properties of the materials should be tuned to improve its therapeutic effect in the host tissue and to become a material able to easily adapt and shape to any type of bone defect. On that account, the use of bioac…
This project aims to obtain hydroxyapatite (HAp) nanoparticles, in which Ca2 + ions will be replaced by Sr2 + in different molar ratios. Sr2 + can replace Ca2 + in the structure of HAp due to similarity of charge and size between these two ions. In addition, the presence of strontium is associated in vivo to the reabsorption control and increased bone formation. This ion is usually admini…
(Only some records are available in English at this moment)
Understanding the bone formation process involves the difficult task to realize how both time and nature acted harmonically in a unique association between calcium phosphate and collagen that gave rise to one of the most remarkable biomaterials we have ever known. The bone consists of a porous hybrid organic/inorganic three-dimensional (3D) matrix, composed mainly by collagen, a variety o…
Biomineralization of hard tissues such as bone and dentin involves a complex spatio-temporal sequence of events regulated by bone-forming cells. One big question that still perdures on the understanding of this process is the origin of the mineral phase. It has been claimed since their discovery in the decade of 1960, that matrix vesicles (MVs) are the entities responsible to nucleate and…
The inorganic compounds present in living organisms are formed by a complex mechanism (biomineralization) which involves steps of nucleation and growth within a confined space. The need of design new bone replacement materials has driven several studies towards the process of bone formation. Bone is a hybrid material formed of plate-like non-stoichiometric hydroxyapatite (HAp) crystals an…
(Only some records are available in English at this moment)
| 4 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 16 / 13 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 25 / 21 | All research grants and scholarships |
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