Graduated in Industrial Pharmacy at Universidade Federal do Rio de Janeiro (1979), Master in Natural Product Synthesis from Universidade Federal do Rio de Janeiro (1983) and Doctorat D`État Ès Sciences Physiques from Universite de Grenoble I (Scientifique Et Medicale - Joseph Fourier) (1987). Has experience in Chemistry, focusing on Organic Synthesis, acting on the following subjects: Morita-Baylis-hillman, organic chemistry, asymmetric synthesis, organocatalysis, stereoselective synthesis and development of new synthetic methods. (Source: Lattes Curriculum)
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The Center for Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborative research projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), the Institute of C…
This research project intends to continue the development of a line of research that explores the Morita-Baylis-Hillman (MBH) reaction, which is an organocatalysed process of formation of a new C-C Ã bond, leading to the synthesis of small poly-functionalized, which can be used as substrate for other chemical transformations. The research proposal was divided into two main projects and ea…
This research has as main target the exploitation of the Morita-Baylis-Hillman adducts as efficient building blocks for the synthesis of molecules of biological interest. The project was divided into two parts. In the first one, we intend to plan, synthesize and evaluated the biological profile of new substances with potential antifungal activity. These new substances were designed based …
Heterocyclic systems are present in many substances that are biologically and pharmacologically active. Among the ten best-selling drugs in the world only one not present in its structure a heterocyclic system. Thus the development of new strategies for the synthesis of heterocycles has both academic and industrial importance. In this research project we propose the use of adducts of Mori…
(Only some records are available in English at this moment)
Chagas Disease and Leishmaniasis are two fatal neglected tropical diseases, with a high worldwide incidence and endemic in Brazil. The therapeutic arsenal currently available for the treatment of these pathologies is limited, expensive and highly toxic. Thus, the development of new drugs for the treatment of these diseases is crucial. In this sense, five hybrid oxadiazole derivatives (hit…
This undergraduated research project intends to synthesize new naphthyridines with potential tubulin inhibitory activity. These compounds can be used as anti-tumoral agents. Previous studies in silico have demonstrated the potentiality of these heterocycles. The required naphthyridines will be prepared according a methodology previously developed in our laboratory, using as building block…
In this undergraduate research project, we intend to evaluate the behavior of Morita-Baylis-Hillman in halo-etherification reactions aiming at the formation of polysubstituted 3- and 4-membered heterocycles. We also intend to evaluate the selectivity for the formation of epoxides and oxetanes and the diastereoselectivity attained, specifically on the generation of epoxides. (AU)
This Master's degree research project has as its main target the proposal of a new synthetic approach for the preparation of a class of anti-inflammatory substances, which were previously synthesized in our laboratory. Based on Morita-Baylis-Hillman adducts, we developed a synthetic strategy that allowed the synthesis of a small series of compounds presenting a very promising anti-inflamm…
(Only some records are available in English at this moment)
This project of research is aimed at exploring new applications for a new bi-functional catalyst. We intend to use this new catalyst in th eMorita-Baylis-Hillman (MBH) reaction with a-keto esters and for the direct formation of indolizines from MBH adducts prepared from 2-pyridinecarboxyaldehydes. (AU)
The project consists on a methodological study of two transformations involving Indolizines obtained from Morita-Baylis-Hillman adducts. They are: an asymmetric transfer hydrogenation reaction and an asymmetric Friedel-Crafts alkylation , both catalyzed by chiral phosphoric acids derived from BINOL. The Indolizines are interesting building blocks, since they can be converted to compounds …
In recent years, there has been an increase in methodology reports aimed to synthesize the 1,2-aminoalcohol core. This key unit is highly sought because of its occurrence in many different organic compounds of value ranging from natural products to pharmaceutical agents. Methods that allow the regioselective and stereospecific addition of nitrogen and oxygen across an alkene are rare, and…
| 1 / 1 | Ongoing research grants |
| 22 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 53 / 26 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 80 / 40 | All research grants and scholarships |
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CV Lattes
ORCID