Abstract
Joint diseases like Osteoarthritis (OA) and Rheumatoid Arthritis (RA) regard to a class of inflammatory diseases highly degenerative, in which the last stage is associated with the irreversible loss of articular cartilage. The Proteinase-Activated Receptor 2 (PAR2) has been hypothesised as a pivotal mediator of joint inflammation, considering that its activation induces joint swelling, le…