Bachelor in Chemistry, Master in Sciences and Doctor in Physical-Chemistry at the State University of Campinas, Brazil. Has been a posdoctoral fellow at the Unitè de Bioinformatique Structurale of the Institut Pasteur in Paris, and at the State University of Campinas. Currently is adjunct professor at the Institute of Chemistry of the State University of Campinas. Works with protein modeling, particularly molecular dynamics simulations, and the application of numerical optimization methods to problems in computational chemistry and biochemistry. (Source: Lattes Curriculum)
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We propose the creation of a world-class multidisciplinary center dedicated to the development and application of advanced computational modeling techniques for the purpose of meeting the challenges in frontier problems in computational engineering and sciences, and promote substantial advancements in technological innovation, education and dissemination of knowledge in the broader area o…
Molecular modeling methods are an integral part of strategies for the determination of protein structures, with or without the use of experimental data. The extent of the role of modeling methods depends on the structural resolution of the experimental data. If the experimental data provides very precise information on the structure, the modeling strategies are used only to finely adjust …
Nuclear Hormone Receptors (NRs) are major targets for pharmaceuticaldevelopment. Many experiments demonstrate that their C-terminal Helix(H12) is more flexible in the Ligand Binding Domains (LBDs) withoutligand, this increased mobility being correlated with transcriptionrepression and human diseases. Crystal structures have been obtained inwhich the H12 is extended, suggesting the possib…
The subject of this postdoctoral research is the structural dynamics and stability of Glycoside Hydrolases (GHs) in aqueous solutions having polyol sugar molecules and ethanol as co-sonvents, which are present in high concentration in industrial processes involving such enzymes. The main purpose of the project is to produce new knowledge about the behavior of such catalysts in non-convent…
Ionic Liquids (ILs) are compounds formed by ions. Many ionic liquids are liquid at temperatures around 25°C. They also show physicochemical properties (low vapor pressure, high thermal stability, high viscosity, dissolution of various compounds, etc.) that make of them potential substances for a wide range of applications (electrochemical devices, catalysis, solvent for chemical reactions…
The structure of proteins and their folding mechanisms are dependent on the molecular environment. Proteins can assume distinct conformations, which might be active or inactive, or even assume different functionalities, as a function of the temperature, pressure, or of the properties of solvent in which they are immersed. Proteins assume their function predominantly in aqueous media. Howe…
Understanding the solvation of saccharides and polysaccharides by solvent mixtures is fundamental for the development of industrial processes of extraction, hydrolysis or derivation. In particular, the process of cellulose dissolution is a difficult and costly step, necessary for its decomposition by enzymes or processes envisaging the production of ethanol. Recently, our group has shown …
This post-doctoral project proposes the development of a new method to determine the quaternary structure of protein complexes by combining experimental methods such as cross-linking and Mass Spectrometry with Molecular Dynamics simulations with Structure-Based model potentials. This strategy can become an efficient and general method to study the function of many cellular mechanisms that…
The Edema Factor (EF) is one of three major toxins involved in the disruption of cellular functions resulting from infection of a host organism by Anthrax. The EF is an enzyme that catalyzes the production of cyclic-AMP (cAMP) from ATP , known as Adenylyl cyclases . In eukaryotes, cAMP is a key signaling molecules and the infection by EF induces its overproduction, leading to cell death. …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 8 / 7 | Completed scholarships in Brazil |
| 16 / 14 | All research grants and scholarships |
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CV Lattes
ORCID