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Shaker Chuck Farah

CV Lattes ORCID


Universidade de São Paulo (USP). Instituto de Química (IQ)  (Institutional affiliation from the last research proposal)
Birthplace: Israel

Graduated in Biochemsitry and Chemistry (1985) and received his Masters in Biochemistry (1988) at the University of Toronto. He received his PhD in Biochemistry from Universidade de São Paulo (1994) where he is now a Full Professor in the Department of Biochemistry and Vice-Director of the Unstitute of Chemistry. His research interests focus on understanding the structural basis of important biological and behavioral processes in bacteria using the phytopathogen Xanthomonas citri as a model. Specific systems under study are 1) signaling pathways involving the important second messenger cyclic diGMP that controls complex behaviours such as the production of virulence factors, motility and biofilm formation, 2) The structure and regulation of the type IV pilus, used by Xantthomonas to migrate across solid surfaces, to organize biofilm structures as well as to interact with bacteriophages. 3) The Xanthomonas Type IV secretion system that mediates the transfer of bacterial toxins to the cells of other bacterial species, 4) Quorum sensing, the means by which members of a bacterial population coordinate their behavior in a manner dependent on cell density. His studies combine a variety of approaches including protein crystallography, Cryo-EM and NMR, other spectroscopic techniques, enzymology, fluorescence microscopy, the production and characterization of Xanthomonas knock-out strains and the analysis of protein interaction networks. Dr. Farah is the Director of the Biology of Bacteria and Bacteriophages Research Center (CEPID B3), a research network with hubs based in São Paulo (IQ-USP, ICB-USP), Campinas (IB-UNICAMP, IAC), Ribeirão Preto (FCFRP-USP, FMRP-USP) and Rio Claro (UNESP) whose mission is to carry out cutting edge basic research into molecular mechanisms that are of prime importance to understand bacterial reproduction, multicellular behavior, competition, colonization and interactions with their eukaryotic hosts and their main predators, the bacteriophages. (Source: Lattes Curriculum)

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