Graduated in Human Medicine by Universidade Estadual Paulista Júlio de Mesquita Filho (1982) and Ph.D. by Program of Post-Graduation "Fisiopatologia em Clinica Medica of Faculdade de Medicina de Botucatu, SP, Brazil (1994). Post Doctoral Program conducted at Tufts University, Boston, MA, USA (1997-1999). She is currently Associate Professor of the Universidade Estadual Paulista Júlio de Mesquita Filho. She has experience in Oxide-Reduction, with an emphasis on antioxidants. It operates on the following topics: lycopene, alpha-tocopherol, heart disease, aging, obesity, intensive care, mechanical ventilation, hemodynamic monitoring. (Source: Lattes Curriculum)
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Cardiotoxicity induced by doxorubicin (DXR), an anthracycline isolated from Streptomyces peucetius, is one of the main secondary pathophisiological events that related to this antineoplasic compound. Cell death resulting from the toxic conditions is associated to deregulated metabolic mechanisms. Intracellular calcium flux and mitochondrial permeability seem to be important factors that l…
Biomarkers of Antioxidant/Oxidative Stress and Their Applications for Human Health (AU)
Majority of researchers with obesity have been shown harmful in antioxidant defense system in obese However, little is known about the evaluation of important dietetic antioxidant lycopene in obesity and in diseases associate with obesity. The study aims to evaluate the oxidative stress level and the effect of supplementation with lycopene in obesity using rats Zucker obese. The study wil…
(Only some records are available in English at this moment)
Cancer is a major public health problem worldwide. Among the treatments used, Doxorubicin (DXO) stands out, a drug used to treat various types of tumors. Despite its effectiveness, DXO has cardiotoxicity as an adverse effect. It is classically accepted that oxidative stress plays a role in the damage mechanism of secondary toxicity of DXO. In order to mitigate and/or prevent cardiotoxicit…
The redox state unbalance corresponds to an important pathogenic pillar in several diseases, such as obesity and its comorbidities. Given the relevance of this event in the pathogenesis of obesity and its complications, several therapeutic strategies using antioxidants have been tested. Lycopene is one of the best antioxidants among carotenoids and although the relationship between lycope…
The imbalance between the production of reactive species (oxygen, ROS and nitrogen, RNS) and antioxidant defense system constitutes the oxidative stress. Due to the relevance of oxidative stress in the pathogenesis of obesity and its complications, several therapeutic strategies using antioxidants have been tested. Lycopene is one of the best antioxidants among the carotenoids and althoug…
(Only some records are available in English at this moment)
In obesity, the increased oxidative stress levels can be a cause of adipose tissue functional alterations. Given the importance of oxidative stress in pathogenesis of adipose tissue, therapeutic strategy using lycopene, a potent antioxidant, may be relevant in an attempt to reduce the ROS overproduction and minimize the consequences of dysfunctional adipocyte. The aim of this study is foc…
| 13 / 8 | Completed research grants |
| 9 / 6 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 24 / 16 | All research grants and scholarships |
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CV Lattes
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