graduation at farmácia from Universidade de São Paulo (2003) and doctorate at Genetics from Universidade de São Paulo (2009). (Source: Lattes Curriculum)
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Gene therapy through viral vectors has great potential, already being used in clinical protocols in humans. Third-generation adenoviral vectors (high capacity, gutless, or helper-dependent-HD) are safer than first-generation vectors and have increased gene insertion capacity; however, its the main limitation for large-scale application is to obtain virus particles free of contamination by…
Microbial agents have been used to fight cancer for over 100 years. Bacteria are capable of inducing death or activating the immune system against tumor cells. Since its initial proposal by William Coley, different bacteria have been used, including Streptococcus, Clostridium and the successful use of the bacillus Calmette-Guérin (BCG) from Mycobacterium bovis to treat bladder cancer. But…
The use of high-capacity adenovirus vectors in cancer therapy has been promising. These vectors are considered safer and with higher cloning capacity in comparison to first and second generations adenovirus vectors. Different approaches can be explored while using adenoviruses as gene carriers, such as inducing the expression of antitumor genes or deleting pro-tumor genes, both leading to…
The recent COVID-19 epidemic is one of the greatest public health challenges of this century. The disease caused social and economic disruption across the world. The ease of transmission of SARS-CoV-2 and its progression to clinical conditions, which in many cases require hospitalization, require redirecting efforts to combat this virus. New or old drugs should be evaluated for activity a…
(Only some records are available in English at this moment)
For over 100 years, microbial agents have been used to fight cancer. Inactivated bacteria are capable of inducing death or activating the immune system against tumor cells. As well as the expression or direct inoculation of bacterial proteins or peptides have also been used in the fight against cancer. There is still a great diversity of bacteria not yet identified and/or poorly studied a…
Gene therapy using viral vectors has a great potential, which is already being used in human clinical protocols. Medullary thyroid carcinoma represents the thyroid malignancy with worst prognosis, featuring great clinical relevance and an ineffective treatment. The development of new therapies, including gene transfer, could be a good option. The Herpes simplex thymidine kinase (HSVtk) ge…
Gene therapy through viral vectors has great potential, and is already being used in clinical protocols in humans. Third-generation adenoviral vectors (high-capacity, gutless, or helper-dependent-HD) are safer than first-generation vectors, but the main concern limitation for their large-scale application is to obtain contamination-free helper virus particles. Adenoviruses of phylogenetic…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 6 / 4 | Completed scholarships in Brazil |
| 12 / 10 | All research grants and scholarships |
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CV Lattes
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