Waldir Pereira Elias Junior in research grants and scholarships supported by FAPESP.
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Diarrhea is an important disease burden worldwide. It causes considerable childhood mortality in the developing world and is associated with morbidity and substantial health care costs also in industrialized countries. Enteroaggregative Escherichia coli (EAEC) are a major cause of acute diarrhea in developing and industrialized regions. So far, the gold standard for EAEC identification is…
Escherichia coli are characterized by harboring both commensal and / or symbiotic strains, as well as strains that are pathogenic to the intestinal and extraintestinal sites of humans and warm-blooded animals. This plurality of behavior is due, on the one hand, to the fact that most of its virulence determinants are encoded in mobile genetic elements and, on the other hand, the extreme pe…
Although Escherichia coli is an abundant component of the normal intestinal microbiota, some strains have acquired virulence factors that have made them pathogenic, causing intestinal or extraintestinal infections. The strains that cause intestinal infections are called diarrheagenic E. coli (DEC), while the extraintestinal E. coli (ExPEC) commonly cause urinary tract infections (UTI) and…
Enteroaggressive Escherichia coli (EAEC) are emerging pathogens associated with cases of diarrhea in children and adults, in both developing and developed countries. In Brazil, EAEC has been found as the most prevalent diarrhea genic E. coli path type. This path type is very heterogeneous regarding the presence of putative virulence factors, indicating a multifactorial profile to cause di…
Enteroaggregative Escherichia coli (EAEC) is an emerging pathogen associated with cases of diarrhea in children and adults, in both developing and developed countries. In Brazil, EAEC has been systematically found as the most prevalent diarrheagenic E. coli pathotype. This pathotype is very heterogeneous regarding the presence of putative virulence factors, indicating a multifactorial pro…
(Only some records are available in English at this moment)
Enteroaggregative Escherichia coli (EAEC) is an intestinal pathogen associated with acute and persistent childhood/adult diarrhea in developed and low-income countries, corresponding to the most prevalent diarrheagenic E. coli pathotype in our country. Asymptomatic colonization by EAEC may leads to malnutrition and impairment of physical and cognitive development in children living in a v…
Extraintestinal pathogenic Escherichia coli (ExPEC) strains are an important cause of infections in humans and their ability to establish an extraintestinal infection is related to the presence of virulence factors. Among the virulence factors produced by ExPEC, the Serine Proteases Autotransporters of Enterobacteriaceae (SPATEs) play important role. They are classified into two classes, …
The serine proteases autotransporters of the Enterobacteriaceae family (SPATE) are related to virulence functions in E. coli, such as adherence, invasion, cytotoxicity, resistance to serum bactericidal activity and biofilm formation. Members of this family are classified into class I (cytotoxic proteins) and class II (immunomodulatory proteins). VAT protease (vacuolating autotransporter t…
(Only some records are available in English at this moment)
Enteroaggregative Escherichia coli (EAEC) is an emerging enteropathogen, associated with acute and persistent diarrhea in children and adults in developed and developing countries. In 2011 a massive outbreak of diarrhea affected many European countries, leading to several deaths due to the development of hemolytic uremic syndrome. This outbreak was caused by a Shiga toxin-producing E. col…
Atypical enteropathogenic Escherichia coli (aEPEC) is one of the most important pathogen causing diarrhea disease worldwide. The hallmark of aEPEC pathogenesis is the ability to cause attaching and effacing (A/E) lesions on intestinal epithelium, a property triggered by proteins encoded on a pathogenicity island called locus of enterocyte effacement (LEE). The A/E phenotype is a dynamic p…
| 2 / 2 | Ongoing research grants |
| 10 / 8 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 17 / 9 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 34 / 24 | All research grants and scholarships |
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