graduate at Medicina from Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (1981) and ph.d. at Phd Of Philosophy Em Farmacologia from University of London (1986). Has experience in Pharmacology, focusing on Clinical Farmacology, acting on the following subjects: nitric oxide, bioavailability, bradykinin, edrf and endothelin-1. (Source: Lattes Curriculum)
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Nitric oxide (NO), is commonly produced within the endothelial cells and is argued to possess potent vasodilatory effects. NO may induce nitration of catecholamine neurotransmitters, resulting in corresponding 6-nitroderivatives. Recently, the 6-nitroderivatives were demonstrated to affect vascular tone and cardiac chronotropy and inotropy. Additionally, a new family of catecholamines, al…
The endothelium is an organ capable of regulating vascular tone through the release of endothelium-derived relaxing factors such as nitric oxide, prostacyclin, etc., or endothelium-derived contracting factors as endothelins, prostanoid. In addition, the current physiological concept poses that such regulation can also occur through the release of exclusively neural-derived catecholamines.…
Professor Tobias Wang is currently one of the leading researchers in the field of comparative physiology, and his research encompasses various regulatory and adaptive issues in vertebrates. His collaboration with my research group at UNICAMP aims to expand the scope of our investigations incorporating evolutionary, adaptive, and integrative aspects. Additionally, it aims to broaden the sc…
The endothelium is an organ capable of regulating vascular tone through the release of endothelium-derived relaxing factors (nitric oxide and prostacyclin - PGI2) and endothelium-derived contracting factors (endothelin - ET1 and prostanoid - PGH2). In addition, the current physiological concept poses that such regulation can also occur through the release of exclusively neural-derived cat…
Reptiles are the first amniotes to develop an intromitent penis, however until now the mechanisms involved in the electrical field stimulation-induced contraction on corpora cavernosa isolated from Crotalus durissus terrificus were not investigated. Crotalus and rabbit corpora cavernosa were mounted in 10 mL organ baths for isometric tension recording. Electrical field stimulation (EFS)-i…
(Only some records are available in English at this moment)
The autonomic nervous system is an important regulator of the cardiovascular system, with adrenergic and cholinergic innervations present in the heart. The endothelium is an organ capable of regulating vascular tone through the release of relaxing agents, such as nitric oxide and prostacyclin, or contractile agents, such as endothelins and angiotensin. Physiologically, this regulation als…
The autonomic nervous system is an important regulator of the cardiovascular system, with adrenergic and cholinergic innervations present in the heart. The endothelium is an organ capable of regulating vascular tone through the release of relaxing agents, such as nitric oxide and prostacyclin, or contractile agents, such as endothelins and angiotensin. Physiologically, this regulation als…
It is classically accepted that the cardiovascular system is essentially modulated by the activity of the autonomic nervous system, with the sympathetic system being responsible for the positive chronotropic and inotropic effects. This view was called into question with the discovery that catecholamines are also produced by endothelium. 6-Nitrodopamine (6-ND) has a more powerful positive …
(Only some records are available in English at this moment)
Introduction: It is well established that endothelial cells modulate vascular reactivity through the release of mediators such as prostacyclin (Moncada et al., 1976), nitric oxide (Furchgott and Zawadzki, 1980) and endothelin (Yanagisawa et al., 1988). Catecholamines modulate vascular tone through actions on ±- and ²-adrenergics (Ahlquist, 1948); meanwhile, the production and release of c…
6-nitrocatecholamines are a class of nitrated catecholamine-derived molecules, which includes 6-nitrodopamine, 6-nitroadrenaline and 6-nitronadrenaline. Current evidence indicates that those molecules are endogenously synthesized and constitute important modulators of cell signaling in different tissues. Vas deferens is one of those tissues whose function is potentialy modulated by 6-nitr…
It is well established that endothelial cells modulate vascular reactivity through the release of mediators such as prostacyclin, nitric oxide and endothelin. Catecholamines modulate vascular tone through actions on ±- and ²-adrenergic agents, however, the production and release of catecholamines are associated with the existence of nerve endings in vessels. Dopamine, a well-known neurotr…
(Only some records are available in English at this moment)
Endothelial cells modulate vascular reactivity through the release of mediators such as nitric oxide and endothelin. The current dogma is that catecholamines modulate vascular tone, chronotropism and cardiac inotropism through their release from adrenergic terminals, and through their action on ±- and beta-adrenergic receptors. We identified, through mass spectrometry, the basal release o…
The identification of the endothelium as a major source for catecholamines, and their role as main modulators of the cardiovascular system, has provoked a change in our understanding of the physiology and pharmacology of the circulation. 6-Nitrodopamine (6-ND) has been described as the most potent endogenous positive chronotropic and inotropic agent ever described, with different mechanis…
6-Nitrodopamine (6-ND) is a newly identified catecholamine released from vascular tissues. Its release is significantly reduced upon pharmacological blockade of NO synthesis with Nx-nitro-L-arginine methyl ester (L-NAME), and it functions as a vasodilator through dopamine D2-like receptor antagonism. Elevated blood pressure induced by L-NAME administration coincides with decreased heart r…
In therapy with immunosuppressant drugs, therapeutic drug monitoring (TDM) is essential to treatment success. Therefore, analytical methods with higher precision, accuracy, sensitivity, selectivity and speed are demanding. This project aims to develop an improved sample-preparation protocol for simultaneous quantification of sirolimus, everolimus, tacrolimus and ciclosporin in whole blood…
The phosphorylation of endothelial nitric oxide (NO) synthase (eNOS) on Tyr81 was shown to increase NO production and blood vessel relaxation in response to agonist stimulation. Although Src has been initially reported to phosphorylate this tyrosine residue, the regulation of the phosphorylation of this site remains largely unexplored. Preliminary work at the Institute for Vascular Signal…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 35 / 23 | Completed research grants |
| 12 / 12 | Ongoing scholarships in Brazil |
| 75 / 26 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 130 / 69 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID