Degree in Pharmacy and Biochemistry from University of São Paulo (USP), Master and PhD in Pharmacology from USP, and Post doctorate from the Massachusetts General Hospital - Harvard Medical School, Boston, USA. Associate-Professor at USP (2003) and Member of the São Paulo State Academy of Sciences (2012) and Head of Department of Pharmacology (2013-2017). He is currently Professor of Department of Pharmacology of the Institute of Biomedical Sciences at USP (2009-). Contributed in the field of Pharmacology and Neuroscience with emphasis on aging and signalling cascade linked to degenerative diseases by introducing new knowledge in studies of adaptive responses associated with hormesis and cognition involving cardiotonic steroids, glucocorticoids, Klotho protein, glutamate and intermittent fasting and . Member of Editorial Board of Plos ONe, Scientific Reports, British Journal Pharmacology, Frontiers in Endocrinology and Brazilian Journal of Medical and Biological Research. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Un efecto inesperado |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Our previous data revealed that the signaling pathways associated with ±-Klotho, glutamate, mediators of the inflammatory response in the central nervous system (CNS) and that related to different isoforms of the Na, K-ATPase (NKA) protein as a pump and receptor for endogenous steroids ( ouabain-like hormones) are associated with neuroplasticity and neuroprotection. This effect induced by…
The modulation of the glutamate activity via NMDA receptor has a strong influence in the adaptive processes that prevent premature aging, as well as play an important role in cognition and degenerative processes. It is well know that the insulin signaling pathways, mediators of the inflammatory response and Na,K-ATPase acting as enzyme and as a receiver of endogenous steroids (hormones wi…
Evidence has shown that OUA is release in a different time-course when compared to GC during a stress response. In addition, OUA also interferes with the CRH transport into the circulation indicating that this hormone plays an important role in the stress response. However, there is no data about the OUA effects during a chronic unpredictable stress. The present work aims to investigate t…
Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury and disease by stimulating adaptive cellular stress responses. However, the impact …
(Only some records are available in English at this moment)
Ouabain is classically known as an endogenous cardiotonic steroid that inhibits Na+/K+-ATPase. Despite knowledge of its synthesis by the adrenals, pituitary and hypothalamus, the physiological role of ouabain has not been fully elucidated. Researchers involved in this proposal have demonstrated that ouabain has anti-inflammatory effects on the immune system and the central nervous system,…
Neurodevelopment, as well as the stages that comprise it, such as proliferation, differentiation and neuronal migration, synapse formation, myelination and synaptic pruning, are dependent on Adenosine Triphosphate (ATP), intracellular calcium buffering and/or the production of Reactive Oxygen Species (EROS). Therefore, all the essential pathways for the development of the Central Nervous …
The highest prevalence of diseases related to aging like Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis, are a result of the increase in life expectancy. Aging is a complex and multifactorial process in which molecular, cellular and behavior alterations can be observed. Inflammation is a common and important factor between many alterations o…
Alzheimer disease (AD) is one of the leading neurodegenerative pathologies in the western world and represents a health and socioeconomic problem. In this context , understanding the mechanisms underlying the pathogenesis of AD would be possible to identify new therapeutic options. The lost of the Endoplasmic Reticulum (ER) calcium homeostasis emerges as a central player in the developmen…
Aging is a complex and multifactorial process, associated with molecular, cellular and behavioral alterations. Oxidative stress, neuroinflammation and excitotoxicity are characteristics common to various neuropathological processes of aging as in Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer's disease. The neuronal damage by excitotoxicity occurs, ma…
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is one of the leading neurodegenerative pathologies in the western world and represents a health and socioeconomic problem. In this context, understanding the mechanisms underlying the pathogenesis of AD would be possible to identify new therapeutic options. Neuroinflammation has an important role in AD. Microglia, the macrophages of the central nervous system pla…
The enzyme Na+,K+-ATPase (Sodium Potassium Adenosine Trisfosfatase) is an integral membrane ion pump, essential to maintain the osmotic balance of cells, by its energy-driven ability to export Na+ and import K+. Its functions are vital to all cells. Of the four ±1-4 subunit isoforms, ±1-3 are expressed in the central nervous system. The ±2 isoform is highly enriched in atrocytes and the ±…
Aging process was always investigated in C. elegans due to its reproductive cycle (they are hermaphrodites) and short lifespan (they live about 2 months). C. elegans life cycle can be indefinitely expanded once animals enter a phase known as dauer. Several genes altering this stage formation were identified and many of these genes codify proteins associated with the only tyrosine kinase r…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 26 / 9 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 39 / 26 | Completed scholarships in Brazil |
| 7 / 6 | Completed scholarships abroad |
| 75 / 44 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID