Principal Investigator at Center for Molecular Biology and Genetic Engineering - Unicamp, Sao Paulo (2012- current) (Source: Lattes Curriculum)
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With the aim of expanding the druggable proteome and lead to the discovery of new medicines, we work on the characterization of understudied human proteins, which show preliminary connection to disease. Within this aim, research has been expanded on the importance of protein related to RNA biology as antibody and drug targets, including the proteins 'per se' and their upstream modulators …
Recent advances have highlighted the advantages of using macrocyclic compounds as a basis for protein kinase inhibitors. However, the design and synthesis methodologies for such macrocyclic inhibitors are at an early stage. SGC-Unicamp works on inhibitor development for several protein kinases which are good candidates for development of macrocyclic inhibitors. Those candidate kinases can…
(Only some records are available in English at this moment)
Chemical fragment-based Hit Discovery (FBHD) is an effective tool for the discovery of lead molecules and was responsible for the development of several FDA-approved drugs. In our group, we study RNA binding proteins containing the KH domain, which allows a protein to bind to a specific set of mRNAs in the cell and to control processes as transport of RNAs from the nucleus and RNA splicin…
The human genome encodes three TRPML (Transient Receptor Potential cation channel, Mucolipin subfamily) proteins. These are evolutionarily related six-transmembrane, Ca2+-permeable, and non- selective cation channels that belong to the large family of Transient Receptor Potential (TRP) ion channels. The TRPML1 is thought to be involved in endo/lysosomal homeostasis and its malfunction is …
Fragment-based Hit Discovery (FBHD) is a new and effective tool for the discovery of lead molecules both in industry and academia and is responsible for the development of several FDA-approved drugs. Its strategy of screening libraries of very small molecules allows for covering a vast chemical space with fewer compounds, which permits an accelerated and cheaper method for drug design whe…
With the aim of expanding the druggable proteome and lead to the discovery of new medicines, we work on the characterization of understudied human proteins, which show preliminary connection to disease. Within this aim, research has been expanded on the importance of protein related to RNA biology as antibody and drug targets, including the proteins 'per se' and their upstream modulators …
With the aim of expanding the druggable proteome and lead to the discovery of new medicines, we work on the characterization of understudied human proteins, which show preliminary connection to disease. Within this aim, research has been expanded on the importance of protein related to RNA biology as antibody and drug targets, including the proteins 'per se' and their upstream modulators …
(Only some records are available in English at this moment)
Protein kinases comprise a large family of proteins responsible for ATP-dependent phosphorylation. This event represents the main post-translation signaling mechanism, controlling most of the human cellular processes. The human genome has approximately 550 kinase proteins (kinome), but only about 15% have been extensively studied, showing the need to expand development of kinase inhibitor…
| 4 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 15 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 23 / 20 | All research grants and scholarships |
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CV Lattes
ORCID