CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC) (Institutional affiliation from the last research proposal) Birthplace: Inglaterra
bachelor's at Ciências Médicas Básicas e Bioquímica from University of London (1983), master's at Cristalografia from University of London (1984) and doctorate at Cristalografia from University of London (1989). Has experience in Byophysics, focusing on Molecular Biophysics, acting on the following subjects: proteínas, schistosoma mansoni, trypanosoma cruzi, transferrins and transferrina. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| The essence of molecules |
| La esencia de las moléculas |
| The essence of molecules |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Septins are cytoskeletal GTP-binding proteins involved in key cellular events including cytokinesis, vesicle trafficking and exocytosis. In humans, different septins self associate in a specific manner to form hexameric or octameric heterocomplexes. These interact via their extremities to form filaments which are capable of assembling into higher order structures. It is known that ectopic…
Septins are cytoskeletal GTP-binding proteins involved in key cellular events including cytokinesis, vesicle trafficking and exocytosis. In humans, different septins self-associate in a specific manner to form hexameric or octameric heterocomplexes. These interact via their extremities to form filaments which are capable of assembling into higher order structures. It is known that ectopic…
To perform their biological functions, proteins must fold into defined three-dimensional structures. These structures are highly conserved, such that ~92 million protein sequences are classifiable in only ~6,000 structures. In these scaffolds, residues that are essential for the chemical origin of protein function are placed in specific positions, thus being highly conserved between prote…
The Gryphon crystallization robot allows for screening conditions using small protein volumes. This equipment leads to a significant gain in productivity facilitating the crystallization of heretofore intractable samples. (AU)
The MALS system permits the precise shape-independent determination of molecular masses and their complexes. Its applicability to different systems, particularly biological macromolecules, makes it versatile and appropriately classified as multiuser. (AU)
The present proposal focuses on structural and functional aspects of the septin family of proteins using an integrated approach involving a series of biophysical and cellular techniques. Despite having been described for the first time 40 years ago in yeast, where they are essential for completing the cell cycle, septins are still considered a neglected component of the cytoskeleton in te…
(Only some records are available in English at this moment)
More than 50 years ago, septins were first described in Saccharomyces cerevisiae. Initially, studies showed that they formed a collar around the budding neck, which was important for the recruitment of proteins for cytokinesis. Today, it is known that septins are ubiquitous in fungi and animals, and may be involved in many important processes in the cell besides cytokinesis, such as phago…
The main role of the postdoctoral fellow will be to consolidate the leading position in septin crystallography that the group proposing the thematic project currently occupies. There are still questions concerning the structure/function relationship of septins that need clarification and where the determination of new crystallographic structures has much to contribute. Considering the exi…
Septins constitute a conserved guanine-binding protein family which are involved in several cellular processes and are capable of self-assembling into heterofilaments and high-order complexes. The human septins are encoded by 13 different genes and are divided into four groups based on their similarity. The C-terminal domain of septins contains characteristic repeats of alpha-helix coiled…
In 2016, during the Zika outbreak in Brazil, an increase of 26 times in microcephaly cases was reported, shocking the country. In these cases, during infection, the virus mainly targets neuronal progenitor cells (NPCs), decreasing their proliferation that leads to cell death, which contributes to microcephaly. By identifying the isolated effect of viral proteins on these cells, Li et al. …
Septins are cytoskeletal GTPases involved in a number of important intracellular processes including cell division, vesicle trafficking, exocytosis, among others. In addition, their role in the formation of barriers which prevent the free diffusion of plasma membrane components has also been reported. In humans, changes in the expression levels of septins are related to several types of C…
Septins are structural proteins that normally present GTPase activity, playing an important role in the cell structure and acting as a scaffold in the recruitment of partner proteins. In order to do so, different septins organize into heterofilaments that are stabilised by interactions between subunits that show two types of interface, known as G and NC interfaces. Understanding the exact…
(Only some records are available in English at this moment)
Septins are membrane-associated GTP-binding proteins which are important in a wide range of physiologically essential processes such as cytokinesis, microtubule dynamics, formation of diffusion barriers and mechanotransduction. The importance of the coiled-coil domains in the formation and maintenance of septin complexes is still not fully understood. It has been almost 15 years since the…
Septins are GTP binding proteins considered to be a novel component of the cytoskeleton. These proteins interact with each other to form filamentous heterocomplexes and higher order structures which are important for cytokinesis, plasma membrane compartmentalization and a variety of other cellular processes. The oligomers themselves can vary in size and composition from species to species…
Septins are GTPases that interact with one another to form filaments and take part in several fundamental cellular processes such as cytokinesis and plasma membrane compartmentalization. Even though there exist a growing interest in this important cytoskeletal component, several aspects of septin polymerization, bundling and function remain unclear. In an attempt to shed light on these qu…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 12 / 9 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 43 / 20 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 67 / 41 | All research grants and scholarships |
| Associated processes | |