Ricardo de Francisco Strefezzi in research grants and scholarships supported by FAPESP.
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The tumour microenvironment includes neoplastic cells which are accompanied by several elements such as extracellular matrix proteins, endothelial cells, pericytes, fibroblasts and leukocytes. Their interactions may promote malignant transformation and increase the tumorigenic phenotype of cancer cells, inducing important phenomena as epithelial-mesenchymal transition, dissemination and m…
Cancer is a complex tissue composed by malignant neoplastic cells surrounded by reactive stroma that contains fibroblasts, as well as inflammatory and endothelial cells, and whose dynamics is currently recognized as primordial for tumor evolution, grown and dissemination. It is believed that almost all solid tumors have atypical fibroblasts in their stromal compartment, known as cancer-as…
(Only some records are available in English at this moment)
Cutaneous squamous cell carcinomas (SCC) represent up to 10% of all skin tumors and their occurrence is mainly associated with exposure to ultraviolet radiation. They are classified into four degrees of differentiation, according to their morphology and keratinization. Surgical removal is usually sufficient for the treatment of cutaneous SCCs in dogs, however, the development of therapies…
Over 70% of cases of mammary tumours in bitches are malignant, highliting inflammatory mammary carcinomas (IMC), a more aggressive variant in dogs and women, which stands out for being a fulminant progressive disease, with high mortality, invasive and metastatic growth. Decorin is considered an important molecule for tumorigenesis and interferes with the E-cadherin-EGFR axis in order to i…
Cancer cells are dependent on the system immune evasion for their survival and evolution. T lymphocyte antitumoral activities can be suppressed through the PD-1/PD-L1 pathway. Antibodies blocking these proteins have been widely used in clinical trials to treat Cancer in humans, and their expressions have been analyzed as prognostic and predictive biomarkers. Canine neoplasms also express …
(Only some records are available in English at this moment)
Cutaneous mast cell tumors are among the most common type of cutaneous neoplasms in dogs. Its etiology is unkown and the biological behavior of this tumor is variable, which makes it difficult to establish efficient therapies. Several prognostic indicators have been studied in attempt to predict the tumor behavior. Inflammation and the immune system are related to tumoral progression and …
Mast cell tumor is one of the most common diagnosed tumors in Small Animal Practice, and it is more frequent in dogs than in cats. It is characterized by the abnormal proliferation of neoplastic mast cells. Although its etiology remains unknown, brachycephalic breeds such as Boxer and Boston terrier are more prone to develop this neoplasm, as well as individuals between seven and nine yea…
Squamous cell carcinoma (SCC) is a malignant neoplasm of epithelial cells that presents slow growth. In companion animals, it is the most common skin tumor in cats and the second most common in dogs. It occurs mainly in tropical regions where there is a higher incidence of ultraviolet rays, affecting animals that have alopecia and/or hypopigmented skin areas. Galectin-3, a protein express…
(Only some records are available in English at this moment)
Radiotherapy is a key treatment modality for brain tumours, but its efficacy is limited by radioresistance. Cancer stem cells (CSC) have been associated with radioresistance and cancer cell survival is influenced by the exosomal content. The purpose of the present research project is to investigate the role of exosomes in the acquisition of resistance to ionising radiation. To test the hy…
Cancer has been reported as the leading cause of death in dogs, surpassing infectious diseases. In bitches, mammary tumors are the most common, accounting for about 50% of cases. Canine mammary carcinoma is the one that occurs most frequently, out of a total of 100,000 animals, it affects about 182 bitches annually. The main immunohistochemical prognostic markers evaluated in canine mamma…
Cancer is the most common cause of death in dogs. Mammary tumours exhibit great histological heterogeneity, preventing the establishment of an accurate prognosis. The histological classification proposed by Goldschmidt and colleagues in 2011 is the most recent reference and is considered the gold standard for defining the prognosis of this disease. With regards to malignancy, the ability …
Cutaneous mast cell tumour (MCT) is the second most frequent malignant neoplasm in dogs. It is a tumour of heterogeneous macroscopic features and variable biological behaviour. Despite having useful prognostic markers, such as histopathological grade and proliferation markers, a search for more specific and precise indicators is still necessary. The successive changes promoted by autophag…
| 1 / 1 | Ongoing research grants |
| 6 / 5 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 8 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 25 / 23 | All research grants and scholarships |
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