CV Lattes
ResearcherID
Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de São Paulo (1971), master's at Microbiology from Universidade Federal de São Paulo (1974) and doctorate at Microbiology from Universidade Federal de São Paulo (1979). Has experience in Pharmacology, acting on the following subjects: paf, eicosanoides, asma, artrite experimental and reacao de arthus. (Source: Lattes Curriculum)
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Obesity is a complex disease that increase mortality and co-morbid diseases such as diabetes and cardiovascular diseases, and is characterized by adipose tissue expansion and inflammation. Recent studies shows that lipid mediators (leukotrienes LTB4 and platelet activating factor PAF) are responsible for chronic inflammation which in turn leads to obesity and insulin resistence. Long-chai…
Macrophages and dendritic cells (DCs) present membrane receptors (PRRs) that recognize microbial structures, Toll-like receptor family being the prototypic receptors of this group. Another group of PRRs recognize altered self components such as oxidized lipids and dying cells and among them the CD36 was the most studied. Stimulation of these receptors induces early generation of lipid med…
The recognition of microorganisms by phagocytes involves complexes of receptors (PRRs) that recognize molecular patterns associated with pathogens (PAMPs), receptors for opsins (Fc gamma to C3b), toll type receptors, in addition to receptors for inflammatory mediators. Evidence exists of interactions between receptors of innate immunity, Fc gamma receptors and receptors for eicosanoids, a…
(Only some records are available in English at this moment)
Type 1 diabetes (T1D) is a metabolic disease related to persistence of low gradesystemic inflammation. Fat mass loss is one of the characteristics of T1D in patients andmice. Our group has shown that T1D mice have high systemic levels of leukotriene B4(LTB4) and this lipid mediator is involved in metabolic alterations as well in systemic andcellular inflammation in T1D animals. We reporte…
Recent evidence suggests the participation of the lipid mediator "Platelet Activating Factor" (PAF) in tumor growth and resistance to chemo-radiotherapy. PAF acts through a G protein-coupled receptor (PAFR), expressed on tumor cells and also on the tumoral infiltrate cells. It has been shown that irradiation leads to the generation of a series of oxidized phospholipids that act as PAFR ag…
Radiotherapy represents an effective method to control cancer locally. But radiation has an important side effect, which is the possibility of inducing the phenomenon of tumor repopulation, where radio-resistant-tumor cells enter an exacerbated proliferation cycle, causing tumor recurrence in a way more aggressive and resistant to therapeutic resources. Recent evidence suggests the involv…
(Only some records are available in English at this moment)
Despite aggressive glucose monitoring and insulin therapy, many patients spend large portions of the day in a hyperglycemic state, placing them at risk for the development of comorbidities. Chronic hypoinsulinemia in diabetes drives systemic inflammation that contributes to many comorbidities, including weight loss, dyslipidemia, low grade inflammation and enhanced risk of infection. Our …
Tumor resistance to therapeutic treatments such as radiotherapy is an importantclinical problem and is an area of active study. Platelet activating factor (PAF) isa lipid mediator of inflammation, and in recent decades, emerged as an importantfactor in tumor outcome. PAF acts by specific binding to its receptor (PAFR),which is present in both tumor cells and cells that infiltrate tumors. …
Leukotriene (LT) B4 is a lipid mediator that acts mostly during inflammatory response, enhancing microbial killing, phagocytosis and leukocyte accumulation. LTB4 acts in cells through two receptors, the high affinity BLT-1 and low affinity BLT-2. Both receptors can be found in several cell types, including immunocompetent cells, such as macrophages, neutrophils and dendritic cells. This l…
(Only some records are available in English at this moment)
| 16 / 7 | Completed research grants |
| 30 / 15 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 51 / 27 | All research grants and scholarships |
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