Dr. Steiner did his undergraduate and graduate training at the University of Sao Paulo (Brazil), having obtained his PharmD in 1999 and his PhD in Physiology in 2002. He did his postdoctoral training at Joseph?s Hospital & Medical Center (Phoenix, AZ, USA) from 2002 to 2007. His first faculty appointment was as an Assistant Professor at the Albany College of Pharmacy & Health Sciences (Albany, NY, USA), where he stayed until 2012. Since then, Dr. Steiner has been a faculty member in Immunology at the Institute of Biomedical Sciences of the University of Sao Paulo, where he currently occupies an Associate Professor position. The Steiner laboratory studies the multilateral interactions among immune system and physiological systems in life-threatening infections (sepsis) and systemic inflammation. The overall goal is to identify the mechanisms by which these systems cooperate or compete with each other under different contexts. Many, but certainly not all, of the cooperative mechanisms rely on the central nervous system as an integrator of immune, physiological and environmental clues. Currently, Dr. Steiner?s research projects fall in one of three lines of investigation: (i) Tissue-specific functions of resident macrophages, their crosstalk, and their neuroendocrine modulation; (ii) Cost-benefit relationship of fever versus hypothermia in bacterial sepsis and fungal infections; (iii) Hemodynamics of septic shock. E-mail: asteiner@usp.br. (Source: Lattes Curriculum)
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Sepsis (systemic inflammation in the setting of infection) is a leading cause of mortality in Brazil and worldwide. A switch in thermal state from fever to hypothermia occurs in the most severe cases of sepsis, which has led to the perception that hypothermia reflects organ failure and is detrimental. We argue that this perception may be premature and incorrect, since there is evidence in…
Sepsis (systemic inflammation in the setting of infection) is a leading cause of mortality in Brazil and worldwide. A switch in thermal state from fever to hypothermia occurs in the most severe cases of Sepsis, which has led to the perception that hypothermia reflects organ failure and is detrimental. We argue that this perception may be premature and incorrect, since there is evidence in…
Septic shock is seen as a condition in which decreases in systemic vascular resistance (SVR) compromise tissue perfusion pressure. In this project, unexpected preliminary results have led us to question the applicability of this model to the most terminal phase of septic shock. We hypothesize that this terminal phase is associated with a switch in hemodynamic profile, with SVR transitioni…
Systemic inflammation is invariably associated with a thermoregulatory response: fever or hypothermia. The mechanisms of the selection between these responses are virtually unknown. We propose that the adipocyte-derived hormone, leptin, links the energy status of a subject to the selection of an appropriate thermoregulatory response during systemic inflammation. Conscious rats will be inj…
There is a two-way communication between the nervous and immune systems.Recent evidence has revealed that the splanchnic nerve, through its sympathetic fibers,suppresses by up to 80% the inflammatory response to a bacterial component, thelipopolysaccharide (LPS). Considering the intimate relationship between inflammation and immunity, this reflex is likely to have implications for infecti…
Cyclooxygenases (COX) are key enzymes in the biosynthesis of lipid mediators that play key roles in inflammation, especially the inducible isoform, called COX-2. The "constitutive" isoform, called COX-1, is seen asan enzyme of importance for "housekeeping" functions, with no role in inflammation.Recent evidence challenges this paradigm by revealing that COX-1 can also beimportant in infla…
(Only some records are available in English at this moment)
Sepsis (systemic inflammation caused by infection) is one of the diseases that most kills in Brazil and worldwide. A change in the thermal state from fever to hypothermia is a milestone in the most severe sepsis. However, while such a phenomenon is generally seen as a sign of disorder and malignancy, recent studies indicate that such hypothermia represents a regulated response whose benef…
(Only some records are available in English at this moment)
As presented in the activity report, the results obtained so far not only question the prematurely accepted pro-inflammatory role of leptin, but, on the contrary, demonstrate that physiological concentrations of leptin exert anti-inflammatory effects. Our results further show that such anti-inflammatory effect does not result from a direct action of leptin on peripheral macrophages. Lepti…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 16 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 26 / 19 | All research grants and scholarships |
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