graduation at Quimica from Universidade Estadual Paulista Júlio de Mesquita Filho (1965) and doctorate at General Biology from Universidade de São Paulo (1972). Has experience in Biochemistry, focusing on Biochemetry of the Microorganisms, acting on the following subjects: neurospora crassa, aspergillus nidulans, fungos, regulação ph and fosfatase alcalina. (Source: Lattes Curriculum)
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Dermatophyte Trichophyton rubrum is the pathogenic fungus with the highest incidence in clinical cases of superficial mycoses in human skin and nails. Although these infections are widespread, the mechanisms associated with successful pathogen-host interaction and drug resistance factors remain misunderstood. Considerable research efforts are being undertaken, aiming at the control of inf…
Dermatophytes are filamentous fungi that use keratin as a nutrient source during infection of skin, nail and hair. Dermatophyte adherence and secretion of enzymes are key factors in the colonization of the host tissues, which can be regulated in response to phosphate levels, different carbon and nitrogen sources, and ambient pH. Dermatophytoses constitute one of the most common fungal inf…
Most microorganisms have evolved signal transduction networks that enable them to survive under conditions of nutrient-limited growth, in the presence of antimicrobial drugs, and during the stressful interaction with the host, among others. The depression of this metabolic machinery also responds to environmental pH signaling, an adaptive response possibly involved in fungal pathogenicity…
The regulation of gene expression is vital for all organisms and is especially required by fungi for rapid adaptation to cellular stress conditions, as is the case when they infect a host or when they are submitted to antifungal drugs. These adaptive mechanisms are extremely complex and most of them have not been fully clarified. The objective of the present project is to continue to expa…
(Only some records are available in English at this moment)
Among the essential gene groups for the development of the infectious process, transcription factors responsible for regulating gene activity stand out [1]. Our group demonstrated the relationship of the transcription factor PacC and the growth of the dermatophyte T. interdigitale in human nails in vitro, confirming its role in fungal pathogenicity [2]. The study of the regulatory mechani…
Dermatophyte and host interaction involves a variety of molecular signals, generated by both the host and the dermatophyte, that allow either installation or its removal by the host. Mechanical signaling, skin pH, adhesion, nutrient uptake, installation, development, and maintenance in the host are part of this signaling. The transduction of molecular signals generated by the insufficienc…
Transcription factors and cell signaling. The dermatophytes-host interactions involve a variety of molecular signals generated by both the pathogen and the host to establish the disease or its elimination by the host. It is part of this signaling the mechanical sensing, pH of the skin, adhesion, nutrient uptake, establishment, development, and maintenance in the host. Transduction of mole…
| 1 / 1 | Ongoing research grants |
| 12 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 19 / 2 | Completed scholarships in Brazil |
| 33 / 11 | All research grants and scholarships |
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CV Lattes
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