graduation at Cristalografia e Mineralogia from Technische Universität Berlin (1981), graduation at Bachelor of Arts from Bangalore University (1975), master's at Master of Arts from Bangalore University (1977), master's at Cristalografia e Mineralogia from Technische Universität Berlin (1984) and doctorate at Cristalografia from Technische Universität Berlin (1987). Has experience in Byophysics, acting on the following subjects: estrutura, cristalografia, cristalização, purificação and cristalografia de proteínas. (Source: Lattes Curriculum)
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The interior of organisms constitute complex, crowded and dynamic environments with little semblance to the experiments conducted on isolated proteins. Data on the possible interactions that specific proteins can participate in within these crowded physiological environments is fundamental to understanding the multiple roles that are frequently played by proteins. High-resolution structur…
The craft beer market in Brazil has been growing exponentially and is against the economic crisis that the country has been facing. In the last decade, production grew 64%, jumping from 8.2 billion to 13.4 billion liters / year and the number of breweries grew by an impressive 292%. In the last 3 years, the number of factories has doubled, reaching more than one thousand registered with t…
This collaborative research project aims to express, characterize and determine the crystal structures of a number of enzymes. Crystallography provides accurate, static images of the three-dimensional structures of biological macromolecules at the atomic level that is unsurpassed by any other technique in its degree of detail and precision.Structural models help elucidate enzyme mechanism…
The Multi-User Equipment Program (EMU) FAPESP has infrastructural nature and is intended for the purchase of scientific instruments characterized by having continuous utility for a group of researchers with extensive experience and proven competence. The program contemplates and encourages the structuring and/or centralized equipment Multi-User laboratories (in certain research areas such…
(Only some records are available in English at this moment)
Mammaliicoccus sciuri is a pathogenic and commensal bacterium with clinical and veterinary importance. M. sciuri was described as the etiological agent of exudative epidermitis in swine and the main virulence factor involved was exfoliative toxin C (ExhC). M. sciuri ExhC also causes epidermal exfoliation in newborn mice, necrosis in renal fibroblasts in newborn hamsters, and inhibition of…
The interior of organisms constitutes a complex, crowded and dynamic environment with little semblance to the experiments conducted on isolated proteins. Data on the possible interactions that specific proteins can participate in within these crowded physiological environments is fundamental in understanding the multiple roles that are frequently played by proteins. High-resolution struct…
(Only some records are available in English at this moment)
Staphylococcus aureus is a bacterium responsible for a wide range of diseases, with the Staphylococcal Scalded Skin Syndrome (SSSS) being one of the most serious. The skin damage in SSSS is caused by S. aureus Exfoliative Toxins (ETs), which are Chymotrypsin-Like Serine Proteases (CLSPs) that cleave the cadherin desmoglein-1 (Dsg-1). Four ETs of the CLSP family have been identified so far…
Staphylococcus sciuri is a commensal and pathogenic bacterium of significant clinical and veterinary relevance. Recently, a strain of S. sciuri has been described as the etiologic agent of Exudative Epidermitis in pigs in China and the main virulence factor involved in this clinical manifestation was the exfoliative protein C (ExhC). ExhC of S. sciuri, in addition to causing epidermal exf…
Staphylococcus sciuri is a commensal and pathogenic bacterium with clinical and veterinary relevance. Recently, a strain of S. sciuri was described as the etiological agent of exudative epidermis in pigs in China and the main virulence factor is linked to clinical manifestation was the exfoliative protein C (ExhC). The ExhC of S. sciuri, in addition to triggering the epidermus in piglets …
(Only some records are available in English at this moment)
Staphylococcus sciuri is a commensal and pathogenic bacterium of significant clinical and veterinary relevance. Recently, a strain of S. sciuri has been described as the etiologic agent of exudative epidermitis (EE) in pigs and the main virulence factor involved in this clinical manifestation was the exfoliative protein C (ExhC). This enzyme belongs to the group of exfoliative toxins (ETs…
Several Staphylococcus spp. express exfoliative toxins (ETs), which act as key virulence factors facilitating host invasion and infection. S. aureus is a notorious pathogen that can produce different ETs (ETA to ETE) causing serious diseases in humans and animals of economic value, such as the staphylococcal scalded skin syndrome (SSSS) and mastitis. Other species, e.g., S. sciuri and S. …
Infections by alpha viruses represent a very serious health problem especially in developingcountries where the precarious public health system is already over stressed. A leading example is infection by the Chikungunya virus which results in considerable social and economic trauma and requires urgent attention. The lack of efficacious treatments is compounded by potential coinfection by …
Infection by flaviviruses cause a variety of diseases, including fevers, encephalitis, and hemorrhagic fevers. NS3 is a multifunctional non-structural protein containing an N-terminal protease domain (NS3pro) that is responsible for the proteolytic processing of the viral polyprotein. NS3 protein is the preferential target for inhibition of replication by avoiding proteolytic processing a…
Grapevine virus A and B (GVA and GVB) are single stranded RNA viruses, responsible for diseases in grapevines and are considered to be of great economic importance for viticulture worldwide. This project aims to understand on the atomic level the proteins considered to be responsible for virus cell-to-cell movement, the mechanism of recognition by cellular components of the vector and its…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 17 / 9 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 26 / 14 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 5 / 4 | Completed scholarships abroad |
| 56 / 35 | All research grants and scholarships |
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