graduate at Biology from Universidade Federal do Rio de Janeiro (1983), master's at Microbiologia from Universidade de São Paulo (1988) and PhD at Molecula Biology from Rijksuniversiteit Gent (1994). He has experience in Genetics, acting on the following subjects: Aspergillus nidulans and Aspergillus fumigatus. (Source: Lattes Curriculum)
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Invasive Pulmonary Aspergillosis (IPA), mainly caused by Aspergillus fumigatus, is a major infectious complication with mortality rates as high as 90% depending on the immunological status of the host. Azoles are fungicidal drugs for A. fumigatus and the main antifungal agents recommended for IPA. Echinocandins, such as caspofungin (CSP), represent a second line therapy and target the fun…
Aspergillus fumigatus is the most important airborne mold pathogen and allergen worldwide. Estimates suggest that over 3 million people have invasive or chronic infections that lead to an excess of 600,000 deaths every year. Only three classes of drugs are currently recommended for the treatment of aspergillosis with the azole class being recommended for primary therapeutic purposes and a…
Fungi are major contributors to human morbidity and mortality but we still know little about the molecular basis of their pathogenicity. Aspergillus-related diseases, collectively known as aspergillosis, are caused by various species in the Aspergillus genus of filamentous fungi. The saprophytic and ubiquitous airborne species Aspergillus fumigatus (section Fumigati) is responsible for mo…
(Only some records are available in English at this moment)
Invasive fungal diseases represent a serious global health problem. Aspergillosis is an opportunistic infection whose etiological agents are filamentous fungi of the genus Aspergillus. More than 60% of aspergillosis cases are caused by Aspergillus fumigatus, while a few other pathogenic species of the genus are responsible for the remainder of cases. Many of these species are closely rela…
This project has the following objectives: (i) to screen the LifeArc library (https://www.lifearc.org/) for compounds that can synergize caspofungin or voriconazole in A. fumigatus wild-type and caspofungin-, and voriconazole-resistant strains (ii) to characterize the mechanisms of action of the most promising compounds found in the LifeArc library, by several tools such as screening of n…
(Only some records are available in English at this moment)
Fungi until a few years ago were considered low dangerous for the health of humans. Currently, as a consequence of the immunological impairment of individuals, caused by diseases or prolonged use of medications, fungi have become clinically relevant, spreading and causing serious infections, being resistant to antifungals and causing fatal diseases. Among the most common fungal infections…
Aspergillus fumigatus is the most ubiquitous of fungi with airborne spores and inhaling of such structures can lead to Chronic Pulmonary Aspergillosis in immunocompromised individuals. The disease is a serious one and mortality can reach 100% if diagnosis is delayed. Essential to A. fumigatus survival both in decaying matter and in host tissues is the ability to sense the environment. G P…
(Only some records are available in English at this moment)
Invasive aspergillosis (IA) due to Aspergillus fumigatus causes extensive morbidity and mortality, especially among immunosuppressed patients. Very few classes of antifungal drugs are available for treating this disease and resistance is developing to first line therapeutics. New agents to treat IA are urgently required. When the fungus invades human lungs, it has to adapt to host environ…
Aspergillus fumigatus is a major human pathogen. Several additional species that are genetically distinct but morphologically identical to A. fumigatus can also cause human infection. These so called "cryptic" species are of increasing worldwide concern due to their clinical occurrence and increased antifungal resistance compared to A. fumigatus. Previous analyses of pathogenicity between…
Aspergillus nidulans predominantly causes infections in patients with a genetic immunodeficiency condition named Chronic Granulomatous Disease (CGD). However, it can also infect other immunocompromised patients. Although A. nidulans causes a severe, often fatal disease, especially in CGD patients, little is known about the fungus-host interaction, and how different strains may induce diff…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 59 / 34 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 75 / 30 | Completed scholarships in Brazil |
| 13 / 12 | Completed scholarships abroad |
| 153 / 82 | All research grants and scholarships |
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CV Lattes
ORCID